埃索美拉唑在老年胃溃疡患者中的疗效及对胃蛋白酶原、cAMP、cGMP的影响观察

Observation on the effect of esomeprazol in the elderly patients with gastric ulcers and influence for the pepsinogen,cAMP and cGMP

目的观察及研究埃索美拉唑在老年胃溃疡患者中的疗效及对胃蛋白酶原、cAMP、cGMP的影响程度。方法选取2015年6月～2016年8月期间诸暨市第四人民医院收治的86例老年胃溃疡患者为研究对象,将其按照随机数字表法分为对照组43例和观察组43例,对照组进行奥美拉唑治疗,观察组则进行埃索美拉唑治疗,然后将2组的临床总有效率、治疗前后的症状评分及胃蛋白酶原、cAMP、cGMP水平进行比较。结果观察组治疗后不同时间的临床总有效率均高于对照组,治疗后的症状评分均低于对照组,血清胃蛋白酶原低于对照组,血浆cAMP及cAMP/cGMP低于对照组,血浆cGMP高于对照组,均有显著性差异（P〈0.05）。结论埃索美拉唑在老年胃溃疡患者中的临床疗效较好,且可显著地改善胃蛋白酶原、cAMP及cGMP表达情况,因此在老年胃溃疡患者中的应用价值较高。

Objective To observe and investigate the effect of esomeprazol in the elderly patients with gastric ulcers and influence for the pepsinogen,cAMP and cGMP.Methods 86 elderly patients with gastric ulcers in our hospital from June 2015 to August 2016 were selected as the research object,and they were randomly divided into control group 43 cases and observation group 43 cases,the control group were treated with omeprazole,the observation group were treated with esomeprazol,the total effective rates,symptom score and pepsinogen,cAMP,cGMP levels before and after the treatment of two groups were compared.Results The total effective rates of observation group at different time after the treatment were higher than those of control group,the symptom scores after the treatment were all lower than those of control group,the serum pepsinogen were all lower than those of control group,the plasma cAMP and cAMP/cGMP were lower than those of control group,the plasma cGMP were higher than those of control group,（P〈0.05）,the differences were all significant.Conclusion The clinical effect of esomeprazol in the elderly patients with gastric ulcers is better,and it can significantly improve the expression situation of pepsinogen,cAMP and cGMP of patients,so its application value in the elderly patients with gastric ulcers is higher.