沙丁胺醇与布地奈德联合治疗支气管哮喘的临床疗效

Clinical effect of combination of salbutamol and budesonide in bronchial asthma

目的探讨沙丁胺醇与布地奈德联合治疗支气管哮喘的临床疗效。方法选取浙江省杭州市余杭区第一人民医院收治的120例支气管哮喘急性发作患者,将其随机分为对照组与实验组2组,每组各60例。对照组患者给予沙丁胺醇单药治疗,实验组患者给予沙丁胺醇与布地奈德合联合用药治疗,用药2 w后比较2组患者喘息,咳嗽,胸闷症状改变及肺功能改善情况。结果治疗后,实验组患者呼吸,哮鸣音,喘息和咳嗽缓解时间明显比对照组时间短,差异有统计学意义（P〈0.05）。对照组患者治疗有效率为78.33%,实验组患者治疗有效率为95.00%,差异有统计学意义（P〈0.05）。实验组肺功能改善情况显著优于对照组,差异有统计学意义（P〈0.05）。结论与单药治疗相比,沙丁胺醇与布地奈德联合用药可以提高支气管哮喘患者的疗效,改善患者的生活质量。

Objective To explore the combination clinical effects of salbutamol and budesonide on bronchial asthma.Methods 120 patients withbronchial asthma in First People＇s Hospital of Yuhang District were selected and randomly divided into two groups of control group and experimental group with 60 cases in each group.Patients in the control group was treated monotherapy with salbutamol,patients in the experimental group were given albuterol and budesonide combination therapy.The treatment effect on symptoms and lung function of the two groups were compared after two weeks.Results After treatment,the breathing,wheezing sound,gasp and cough remission time were significantly shorter in the experimental group than in the control group,the difference was statistically significant（P〈0.05）.The effective rate of the control group was 78.33%,the effective rate of the experimental group was 95.00%,the difference was statistically significant（P〈0.05）.The improvement of lung function in the experimental group was significantly higher than that in the control group,the difference was statistically significant（P〈0.05）.Conclusion Compared with monotherapy,the combination of salbutamol and budesonide can improve the efficacy of bronchial asthma patients and improve the quality of life of patients.