水蛭唾液腺分泌物活性物质的功能多样性及其应用

The functional diversity of leech salivary gland secretions and its application

水蛭唾液腺分泌物中含有100种以上的生物活性物质,近几年已成为许多研究人员关注的热点,其中研究最为广泛和深入的是水蛭唾液腺分泌的具有抗凝血及抑制血小板聚集的生物活性物质,并且有些种类已经成功应用到心脑血管疾病的治疗中。除此之外,越来越多的研究发现,水蛭唾液腺分泌物中还存在具有抑菌、抗肿瘤、镇痛、血管扩张、消炎、促进伤口愈合等生物学功能的活性物质。因此,水蛭唾液腺分泌物具有生物学功能的多样性。而且,水蛭不仅仅应用于人类疾病的治疗,也应用于几种动物的疾病治疗。本文通过查阅大量文献,对水蛭唾液腺分泌物的功能多样性进行阐述,旨在为水蛭唾液腺分泌物的利用及其它吸血动物唾液腺分泌物功能的研究提供有益的参考。

Secretion of the salivary glands of leeches contains more than 100 bioactive substances,in recent years it has become the focus of many researchers＇ attention,which was the most extensive and in-depth study of the salivary glands of leeches anticoagulant and inhibit the biological activity of platelet aggregation substance,and some species have been successfully applied to the treatment of cardiovascular diseases.in addition,a growing number of studies have found that leech salivary gland secretion also has antibacterial,antitumor,analgesic,vasodilator,anti-inflammatory,wound healing and other biological functions.Thus,leech salivary gland secretion with functions of biological diversity.Moreover,the leech is not just for the treatment of human diseases,but also applied to the treatment of several diseases of animals.This review expatiating the functional diversity of leech salivary secretions by consulting a large number of iterature,that the use of leech salivary gland secretion and other blood-sucking animal salivary gland secretions functions provide a useful reference.