抗肾素-血管紧张素系统药物在抗肿瘤中的作用

Effect of Anti-Renin Angiotensin System Drugs in Tumors

最初,肾素-血管紧张素系统(RAS)被认为在调节心血管功能、维持水电解质平衡等方面发挥着重要作用,并基于此研发出多种靶向药物应用于高血压的治疗。随着这些药物的大规模临床应用,RAS抑制药被发现对部分肿瘤发展具有显著抑制作用,从而揭示了RAS在细胞增殖、分化、血管生成、肿瘤发生等生理过程中也发挥着重要作用。该文就RAS在肿瘤发生发展中的作用进行综述。

Initially, the renin-angiotensin system（ RAS） was considered to play an important role in regulating cardiovascular function and maintaining the balance of water and electrolyte. Based on this, several targeted drugs in the treatment of hypertension were developed. With the large-scale clinical application of these drugs,RAS inhibitors are found to has a significant inhibitory effect on some of the tumor development,which reveals the RAS function in cell proliferation,differentiation,angiogenesis and tumor occurrence. In this paper, the important physiological function of RAS in tumor occurrence and development were reviewed.