稳定期精神分裂症患者精神症状、认知功能与社会功能的相关性

Associations between social function and cognitive function,psychopathology in clinically stable patients with schizophrenia

目的探讨稳定期精神分裂症患者认知功能、精神症状与社会功能的相关性,以进一步了解社会功能的影响因素。方法以连续入组的方式,在罗定市第三人民医院入组符合《精神障碍诊断与统计手册(第4版)》(DSM-Ⅳ)精神分裂症诊断标准的稳定期患者116例。采用阳性和阴性症状量表(PANSS)、精神分裂症认知功能成套测验共识版(MCCB)及个人和社会功能量表(PSP)分别评定患者的精神症状、认知功能及社会功能。采用线性回归及Logistic回归分析PSP、工作/学习、婚姻状态的影响因素。结果线性回归分析显示,PANSS阴性症状与PSP评分呈负相关(B=-0.323,P=0.004),加工速度、言语学习与记忆、社会认知与PSP评分呈正相关(B=0.270,0.243,0.141,P<0.05或0.01)。Logistic回归分析显示阴性症状是工作/学习、婚姻的危险因素(OR=0.863,0.891,P均<0.05),加工速度是其保护因素(OR=1.125,1.060,P<0.05或0.01)。结论稳定期精神分裂症患者的社会功能可能与阴性症状、加工速度、言语学习与记忆、社会认知密切相关。

Objective To examine the associations between cognitive function, psychopathology and social function in clinically stable schizophrenia patients, which aimed to investigate affecting factors in social function. Methods A total of 1 1 6 stable schizophrenia patients who met the DSM - IV diagnostic criteria were recruited in the Third Peoples Hospital of Luoding. The Positive and Negative Symptom Scale （PANSS） , the MATRICS Consensus Cognitive Battery（ MCCB） , the Personal and Social Performance Scale （PSP） were used to evaluate psychotic symptoms, cognitive function and social function, respectively. Linear regression analysis was used to identify independent predictors of social function. Logistic regression analysis was used to identify independent predictors of employment/study and marriage separately. Results I n linear regression analysis, negative symptom wa s negatively correlated with PSP score（B = - 0. 323, P =0.004）,while the scores on speed of processing, verbal learning and memory, social cognition were positively correlated with PSP score（B =0. 270, 0. 243 , 0. 141, P 〈0. 05 or 0. 01） . In Logistic regression analysis, negative symptom was a risk factor of employment/study and marriage （ OR - 0. 863 , 0. 891 , P 〈 0. 0 5 ） , while the speed of processing was protective factor of employment/study and marriage（ OR - 1. 1 2 5 , 1. 060, P 〈 0. 05 or 0. 0 1 ）. Conclusion The result shows that negative symptom, speed of processing, verbal learning and memory, social cognition are independently associated with social function in clinicallystable patients with schizophrenia.