双相障碍的免疫学研究进展

Immunological research development of the bipolar disorder

双相障碍是一类病程复杂、治疗难度大、致残率高的慢性精神疾病。在过去的几十年中,虽然对双相障碍的研究取得了一定进展,但其确切的病因及发病机制仍不明确。近年来,越来越多的研究显示免疫系统失调可能是双相障碍的一个发病机制。本文总结了双相障碍患者外周血及中枢神经系统炎症因子的研究,并探讨了以炎症因子为靶点的免疫治疗方法在双相障碍治疗中的研究进展。

Bipolar disorder is a chronic psychiatric disease,associated with complex course, treatment - resistant and high disability rate. In the past decades,a certain amount of progress had been made in the study of bipolar disorder, but its exact etiology and pathogenesis remained poorly understood. In recent years, more and more studies showed that immune dysfunction may play a significant role in the pathogenesis of bipolar disorder. This review summarized the researches of the inflammation factors in peripheral and central nervous system among the bipolar patients, and discussed novel therapeutic strategies that emerged from these studies.