天舒胶囊治疗偏头痛的临床疗效及对血管内皮功能和血流动力学的影响

The clinical curative effect of Tianshu capsule in the treatment of migraine and its influence on vascular ;endothelial function and hemodynamics

目的：探讨天舒胶囊治疗偏头痛的临床疗效及其对血管内皮功能、血流动力学的影响。方法选取80例偏头痛患者为观察对象，并按其治疗方法的不同将其均分为对照组与观察组，对照组予以口服盐酸氟桂利嗪胶囊治疗，观察组在对照组的基础上予以口服天舒胶囊治疗，观察两组的临床疗效以及治疗前后的血流动力学[（大脑中动脉（MCA）、大脑前动脉（ACA）、大脑后动脉（PCA）的收缩期峰值流速（Vs）以及舒张期峰值血流速度（Vd）]指标、内皮素（ET）指标等。结果观察组总有效率（97．50％）明显高于对照组（75.00％）（χ2＝8．54，P＜0．05）；而血流动力学与内皮素的相关指标均较治疗前有所降低，且观察组治疗后MCA、ACA、PCA的Vs分别为（105．02±1．12）cm／s、（80．22±1．10）cm／s、（60．34±1．20）cm／s与MCA、ACA、PCA的Vd值（35．22±1.13）cm／s、（40．33±1．21）cm／s、（21．23±1．12）cm／s均大幅度低于对照组（120．10±1．13）cm／s、ACA（95．33±1．12）cm／s、PCA（80．21±1．13）cm／s 和（42．33±1．10）cm／s、ACA（50．23±1．10）cm／s、PCA（30．21±1．10）cm／s，差异均有统计学意义（t＝25．46、25.76、33．38，12．30、17．04、15．55，均P＜0．05）。结论天舒胶囊治疗偏头痛的临床疗效显著，可有效改善患者的脑血流速度以及血管舒张功能，值得推广。

Objective To investigate the clinical efficacy of Tianshu capsule in the treatment of migraine and its influence on vascular endothelial function,hemodynamics.Methods 80 patients with migraine from October 2014 to October 2015 in our hospital were selected as the research subjects,and according to the different treatment methods, they were divided into control group and observation group.The control group was treated with oral flunarizine hydrochloride capsules,the observation group was given Tianshu capsule on the basis of the treatment of the control group.The blood dynamics of the two groups before and after treatment and the clinical curative effect of the patients [the middle cerebral artery （MCA）,anterior cerebral artery （ACA）,Fu （PCA）after artery peak systolic velocity （Vs）and diastolic peak flow velocity （Vd）index,endothelin （ET）index]were observed.Results The curative effect of two groups was significantly improved compared with before treatment,the total effective rate of observation group （97.50%）was significantly higher than the control group （75.00%）（χ2 =8.54,P〈0.05）.The related indices of hemodynamics and endothelium were lower than before treatment,and after treatment,Vs of MCA,ACA,PCA in the observation group were （105.02 ±1.12）cm/s,（80.22 ±1.10）cm/s,（60.34 ±1.20）cm/s,Vd of MCA,ACA,PCA in the observation group were （35.22 ±1.13）cm/s,（40.33 ±1.21）cm/s,（21.23 ±1.12）cm/s,which were signifi-cantly lower than those in the control group[Vs of MCA,ACA,PCA：（120.10 ±1.13）cm/s,（95.33 ±1.12）cm/s, （80.21 ±1.13）cm/s;Vd of MCA,ACA,PCA：（42.33 ±1.10）cm/s,（50.23 ±1.10）cm/s,（30.21 ±1.10）cm/s] （t=25.46,25.76,33.38,12.30,17.04,15.55,all P〈0.05）.Conclusion The curative effect of Tianshu capsule in the treatment of migraine was improved in patients with cerebral blood flow velocity and vascular diastolic function, and is worthy of promotion.