阻塞性睡眠呼吸暂停综合征氧化应激反应的分子机制与脑卒中的关联性研究进展

Advances of molecular mechanisms of oxidative stress in obstructive sleep apnea syndrome and stroke

阻塞性睡眠呼吸暂停（OSA）是一种发病率高且具有一定潜在危险的疾病，以夜间睡眠打鼾中反复间断性低氧血症、高碳酸血症为特征，是缺血性脑卒中的独立危险因素，目前多项研究证实OSA与氧化应激密切相关，本研究就氧化应激在OSA与脑卒中发生的相关性，如促进动脉粥样硬化、损伤线粒体、缺血再灌注损伤、缺血预处理的复杂机制加以综述，从分子机制探讨氧化应激对于OSA及脑卒中的关系。

Obstructive sleep apnea （OSA）is a high incidence of potentially dangerous disease,characterized by intermittent hypoxia or hypercapnia.It is an independent risk factor for ischemic stroke.Currently a number of studies have confirmed OSA closely associated with oxidative stress.In this paper,the complex mechanisms of oxidative stress in the OSA and the occurrence of stroke will be reviewed,such as promoting atherosclerosis,damaging the mitochondria,ischemia -reperfusion injury,ischemic preconditioning.To investigate the relationship between OSA,oxidative stress and stroke from molecular mechanisms.