广州地区发热呼吸道症候群病原学研究

Etiological study on febrile respiratory syndrome in Guangzhou area

目的探讨广州地区发热呼吸道症候群病原谱构成,为临床诊断、治疗和预防策略提供科学依据。方法采集2014年-2015年本院就诊的发热呼吸道症候群895例患者的痰液及咽拭子标本,分别进行细菌学培养和肺炎支原体、8种病毒的核酸检测。结果 895例患者中,病原学检出阳性350例,检出率为39.1%,其中439份痰液标本培养共分离64株病原菌,主要为真菌、铜绿假单胞菌和金黄色葡萄球菌;849份咽拭子中,检出肺炎支原体、病毒核酸阳性325例,主要是流感病毒、鼻病毒和呼吸道合胞病毒。细菌合并病毒感染的患者15例,病毒合并支原体感染10例,多重病毒感染15例。结论构成广州地区发热呼吸道症候群病原谱种类繁多,以病毒感染为主,且以流感病毒、鼻病毒和呼吸道合胞病毒多见,混合感染常见。

Objective To explore the pathogen spectrum constitution of febrile respiratory syndrome in Guangzhou area,in order to provide scientific basis for clinical diagnosis,treatment and prevention. Methods Sputum and pharyngeal swab specimens were collected from 895 patients with febrile respiratory syndrome during 2014- 2015 in our hospital respectively for the detection of bacteriological culture,mycoplasma pneumonia and 8 kinds of virus nucleic acid. Results 350 positive cases were detected from 895 samples,with a positive rate of 39. 1%. Among which 64 strains of pathogenic bacterium were separated from439 cultured sputum,and the fundamental fields were Fungus,Pseudomonas aeruginosa and Staphylococcus aureus. 325 strains of Mycoplasma pneumonia and viral nucleic acid were detected in 849 throat swab samples,and the fundamental fields were Flu,HRV and RSV. There were 15 cases of bacteria associated with virus infection,10 cases of virus and Mycoplasma infection,and15 cases of multiple viral infections. Conclusion Febrile respiratory syndrome in Guangzhou area were constituted in a wide variety of pathogens,which was mostly caused by viruses,mainly as Flu,HRV and RSV. Moreover,mixed infections are also common.