吴茱萸碱对高脂血症小鼠血脂水平及血液黏稠度的影响

Effect of Evodiamine on Blood Lipids and Blood Viscosity in Hyperlipidemic Mice

目的:观察吴茱萸碱对高脂血症小鼠血脂水平及血液黏稠度的影响。方法:将60只小鼠随机分出12只为正常组,其余48只进行造模,将造模成功的40只小鼠随机分为对照洛伐他汀组、模型组、吴茱萸碱高剂量组和吴茱萸碱低剂量组,每组各10只。给药组每天早上灌高脂饲料20 m L·(kg·d)^(-1),下午灌药:吴茱萸碱高剂量组给予吴茱萸碱溶液30 m L·(kg·d)^(-1),吴茱萸碱低剂量组给予吴茱萸碱溶液10 m L·(kg·d)^(-1);洛伐他汀组给予洛代他汀水溶液3 mg·(kg·d)^(-1),模型组给予高脂饲料20 m L·(kg·d)^(-1),正常组给予基础饲料。检测血清三酰甘油(three acyl glycerin,TG)、血清总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)含量和血液黏稠度。结果:与正常组比较,模型组TC、TG、LDL-C含量明显增高,HDL-C降低,差异具有统计学意义(P<0.05);与模型组比较,洛伐他汀组和吴茱萸碱高剂量组TG、TC、LDL-C含量显著降低,HDL-C含量升高明显,差异具有统计学意义(P<0.05);吴茱萸碱低剂量组TG、TC、LDL-C含量变化不明显,差异无统计学意义(P>0.05)。与模型组比较,洛伐他汀组、吴茱萸碱低剂量组及吴茱萸碱高剂量组血液黏稠度明显降低,差异具有统计学意义(P<0.05)。结论:吴茱萸碱具有降低高脂血症小鼠TC、TG、LDL-C及血液黏稠度,升高HDL-C的作用。

Objective：To study the effect of evodiamine on blood liqids and blood viscosity in hyperliqidemia mice. Methods：Sixty mice werernndomlv divided into one normal group （12 cases） and the other 48 cases were made to animal models. The 40 micewith successful moleling were randomly divided into：control lovastatin group, model group, low-dosage evodiamine group, high- dosage evodiamine group,with 10 cases in each group. The administration group was fed by high fat diet （20 mg·（kg·d）（-1）） inthe morning and administrated with evodiamine at dosage of 10 mg·（kg·d）（-1）and 30 mg·（kg·d）（-1） respectively. Lovastation group were administered with lovastatin at the dosage of 3 mg·（kg·d）（-1） ,and model group were administered at the dosage of 20 mg·（kg·d）（-1）. The normal was fed with normal diet. The contents of TG, TC, LDL-C, HDL-C and blood viscosity were de-tected. Results：The content of TC,TG and LDL-C in model group increased obviously and HDL-C decreased compared with the normal group;there was significance difference （P 〈 0.05 ）. Compared with model group, the content of TG, TC and LDL-C in lov- astatin group, high-dosage evodiamine group decreased and the content of HDL-C increased apparently than model group; the difference was significant（ P 〈 0.05 ）. The level of TG, TC and LDL-C didn＇t change markedly;the difference had no statistical significance（P 〉 0.05）. Compared with model group,the blood viscosity in lovastatin group,high-dosage evodiamine groups and low-dosage evodiamine group decreased remarkably, with statistical difference （P 〈 0.05 ）. Conclusion： Evodiamine can decrease the levels of TC, TG, LDL-C and blood viscosity and increase the content of HDL-C in hyperlipidemic mice.