IL-4-590C/T基因多态性与儿童支气管哮喘关系的Meta分析

The association between the polymorphisms in the IL-4-590C/T gene and children asthma disease:a Meta analysis

目的探讨白细胞介素4(IL-4)基因-590C/T(rs2243250)多态性与儿童支气管哮喘(简称哮喘)发病风险的相关性。方法计算机检索CNKI期刊全文数据库、万方医学期刊数据库、维普医药信息资源系统、Pubmed、百度学术、谷歌学术有关IL-4基因-590C/T多态性与儿童哮喘发病风险的病例-对照研究,检索时限均为从建库至2016年1月。采用RevMan 5.2软件和Stata12.0软件进行Meta分析,计算合并OR值以及95%可信区间(CI)。结果最终纳入7个病例对照研究,共计哮喘患者1 167例为病例组和1 101例健康者为对照组。Meta分析结果显示,5种遗传基因型CT+CC和TT,CC和CT+TT,CC和TT,CC和CT,C和T都可增加儿童支气管哮喘发病风险,5种基因型的OR(95%CI)分别为0.7(0.57~0.85),0.56(0.43~0.72),0.46(0.33~0.64),0.64(0.48~0.85),0.45(0.27~0.77);人种亚组分析结果显示,在亚洲人群中基因型CC和CT+TT,CC和TT,CT和TT,C和T与儿童支气管哮喘发病风险存在相关性,OR(95%CI)分别为0.50(0.35~0.72),0.50(0.27~0.95),0.61(0.41~0.92),0.47(0.23~0.95),P值分别为0.01、0.04、0.02、0.03,在非亚洲人群中基因型CC和CT+TT,CC和TT,CC和CT与儿童支气管哮喘发病相关OR(95%CI)分别为0.63(0.44~0.90),0.49(0.25~0.96),0.67(0.45~0.98),P值分别为0.01、0.04、0.04。结论 IL-4基因-590C/T多态性与儿童支气管哮喘易感性相关。

Objective To investigate the relationship between polymorphism of IL-4-590C/T and susceptibility of asthma.Methods The case-control articles reporting the relationship between IL-4-590C/T polymorphism and susceptibility of asthma were collected by China National Knowledge Infrastructure,WanFang data,VIP citation databases,Pubmed,Baidu Scholar,time limits are retrieved from the building a database to January 2016.The Meta-analysis software RevMan5.0and Stata 12.0was applied for heterogeneity test and pooled ORcalculation.Results Seven case-control studies were selected,including 1 167 cases in the asthma group and 1 101 cases in the control group.Meta-analysis showed that both-590C/T polymorphisms genotypes were significantly associated with asthma,five kinds of senotypes OR（95%CI）were CT＋CC vs.TT[0.7（0.57-0.85）],CC vs.CT＋TT[0.56（0.43-0.72）],CC vs.TT[0.46（0.33-0.64）],CC vs.CT[0.64（0.48-0.85）],C vs.T[0.45（0.27-0.77）].From subgroup analysis,genotype CCvs.CT＋TT[0.50（0.35-0.72）],CCvs.TT[0.50（0.27-0.95）],CTvs.TT[0.61（0.41-0.92）],C vs.T[0.47（0.23-0.95）]with risk correlated in Asian children asthma（Pvalue is 0.01,0.04,0.02,0.03）.Genotype CC vs.CT＋TT[0.63（0.44-0.90）],CC vs.TT[0.49（0.25-0.96）],CC vs.CT[0.67（0.45-0.98）]also indicated a significant correlation between-590C/T polymorphisms of IL-4and asthma in non-Asian children（Pvalue is 0.01,0.04,0.04）.Conclusion Current evidence suggests that the-590C/T polymorphism of IL-4gene is associated with children asthma.