人工剥离胎盘与产后出血的系统回顾和Meta分析

Manual removal of the placenta in the prevention of postpartum hemorrhage:a Meta-analysis review of randomized controlled trials

目的探讨人工剥离胎盘干预第三产程对产后出血的影响。方法电子检索PubMed、EMBASE数据库、EBSCOhost数据库及中国期刊全文数据库、中国优秀博士学位论文全文数据库、中国优秀硕士学位论文全文数据库、中国重要会议论文全文数据库、维普中文科技期刊数据库、中国生物医学文献数据库(cBMdisc)、万方数据库所有公开发表的(截止至2015年10月)人工剥离胎盘积极干预第三产程用于预防产后出血的临床随机对照试验,进行质量评价后用RevMan4.2软件进行Meta分析。结果总共6个随机对照试验涉及2 435例参与者是合格的,其中剖宫产占5项,自然分娩占1项;英文文献占4项,中文文献占2项。剖宫产组人工剥离胎盘产后出血较对照组明显增加,自然分娩组没有大样本数据。结论剖宫产中应等待胎盘自然剥离,而自然分娩是否应利用人工剥离胎盘积极干预第三产程还待进一步的研究。

Objective To determine the specific effect of manual removal of the placenta in the third stage of labor in the prevention of postpartum hemorrhage.Methods We searched PubMed,EMBASE,EBSCOhost databases and Chinese Academic Journal et al（inception to October August 2015）.Articles database of all published.Randomized controlled trials comparing manual removal of the placenta with hands-off management in the third stage of labor were included.Two independent reviewers assessed the included studies and extracted data.RevMan4.2software was used for Meta-analysis.Results Six randomized controlled trials involving a total of 2 435 participants were eligible.There were five cases of cesarean section,one case of natural childbirth,and four English literatures and two Chinese literatures.Significant difference was found between manual removal of the placenta and handsoff management groups with respect to the incidence of postpartum hemorrhage.Conclusion Routine manual removal of placenta at cesarean section significantly increases perioperative blood loss.However,the effect in vaginal delivery need further research.