两种红细胞制品治疗阵发性睡眠性血红蛋白尿症的疗效比较

Comparison on the efficacy of two kinds of red blood cell products on paroxysmal nocturnal hemoglobinuria

目的分析两种红细胞制品治疗阵发性睡眠性血红蛋白尿症(PNH)的治疗效果,为临床治疗提供依据。方法将2009-2014年入院治疗的50名PNH患者作为研究对象,将其按照输注红细胞制品分为去白悬浮红细胞组和洗涤红细胞组,观察两组患者输血疗效及输血不良反应。结果去白悬浮红细胞组和洗涤红细胞组的血液成分输注后红细胞(RBC)增值、血红蛋白(Hb)增值和红细胞比容(Hct)增值比较,差异无统计学意义(t=0.737,P=0.462;t=0.795,P=0.428;t=-0.006,P=0.995)。两组输血不良反应发生率较低(χ~2=0.318,P=0.573),均未出现明确的溶血性输血不良反应。结论去白悬浮红细胞治疗阵发性睡眠性血红蛋白尿症贫血疗效确切,输血不良反应并未增加,值得临床推广。

Objective To compare the efficacy of two kinds red blood cell products transfusion in paroxysmal nocturnal hemoglobinuria（PNH） and provide evidence for clinical blood transfusion. Methods Fifty patients with PNH were selected from hospital from 2009 to 2014. They were divided into leukocyte-depleted red cells suspension group and wash redcells group according to the transfusion of blood products.Transfusion efficacy and adverse transfusion reactions were observed in two groups. Results There was no significant difference on the degree of RBC,HB and Hct rising between the leukocyte-depleted red cells suspension group and the group of wash red cells（t=0.737,P=0.462;t=0.795,P=0.428;t=-0.006,P=0.995）. The incidence of adverse transfusion reactions in two groups was similar and low（χ^2=0.318,P=0.573）.There were no clear hemolytic transfusion reactions in two groups. Conclusion Transfusion of leukocyte-depleted red cells suspension could improve the status of patients with PNH without the repercussion of adverse transfusion reactions. These types of blood product were worthy for clinical application.