甲型和乙型流感阳性儿童患者C反应蛋白和白细胞结果分析

Analysis of C-reactive protein and white blood cells counts in children with influenza A and influenza B

目的探讨甲型和乙型流感病毒(FA-RNA/FB-RNA)阳性儿童患者C反应蛋白(CRP)和白细胞数的变化及意义。方法对2013-2015年广州医学院荔湾医院门诊及住院的有发热和呼吸道感染症状儿童患者进行咽拭子采样,提取DNA后用聚合酶链反应法检测甲型和乙型流感病毒基因,同时采集外周血检测血常规和CRP。结果 2 609例标本中检出甲型流感病毒阳性124例,占4.75%,乙型流感病毒阳性72例,占2.76%,男女患儿间阳性率比较差异无统计学意义(P>0.05)。甲型流感组和乙型流感组WBC计数、中性粒细胞计数和CRP均低于对照组,差异有统计学意义(P<0.05),而甲型流感组与乙型流感组之间各指标比较差异无统计学意义(P>0.05)。甲型流感组和乙型流感组在白细胞>10×10~9/L、中性粒细胞计数>7.0×10~9/L、CRP>5 mg/L各项中的构成比与对照组比较,差异有统计学意义(P<0.05),而甲型流感组与乙型流感组之间各指标比较差异无统计学意义(P>0.05);男女患儿间甲型流感和乙型流感的白细胞计数、中性粒细胞计数和CRP均值比较,差异均无统计学意义(P>0.05)。结论检测流感患儿的CRP和WBC水平,能较好地协助临床判断病情和指导用药。

Objective To investigate the changes of C-reactive protein（CRP） level and white blood cell（WBC） count level in children with influenza A and influenza B. Methods Outpatient and hospitalized patients with respiratory infection symptoms were sampled for pharyngeal swab from 2013 to 2015. RNA was extracted for detecting influenza A and influenza B gene by PCR. Blood routine and CRP were detected from blood samples.Results There were 124 cases of influenza A-RNA positive（4.75%） and 72 cases of influenza B-RNA positive（2.76%） from 2 609 cases in children with respiratory tract infection; there was no difference between boys and girls in positive rate（P〉0.05）.In influenza A group and influenza B group,the WBC,NE and CRP level were also lower than those of control group（P〈0.05）. There was no statistical significance between influenza A and influenza B group in each index（P〉0.05）. In influenza A group and influenza Bgroup,the constituent ratio of WBC（〉10×10^9/ L）,NE（〉7.0×10^9/L） and CRP（〉5 mg/L） were also lower than those of control group（P〈0.05）. There was no statistical significance between influenza A and influenza B group in each index（P〉0.05）.There was no difference between boys and girls in WBC, NE and CRP level（P〉0.05）too. Conclusion Detection of CRP and WBC levels in children with influenza,can better assist in clinical judgment and guidance medication.