术中区域性缓释化疗在中晚期食管癌综合治疗的临床效果

To investigate the clinical analysis of intraoperative regional extended release chemotherapy for advanced esophageal cancer

目的探讨术中区域性缓释化疗在中晚期食管癌综合治疗的临床效果,为中晚期食管癌患者的临床治疗提供有效的治疗方案。方法选取2011年1月至2016年6月间在江苏省中医院治疗的中晚期食管癌患者90例,随机分为实验组和对照组,每组45例。两组均采用食管癌根治术治疗,实验组在手术中局部植入混合化疗药物进行间质治疗,对照组仅进行单纯的手术治疗。两组患者在术后均进行常规化疗,且化疗方案相同。比较两组患者术后并发症、化疗不良反应、复发及生存情况。结果实验组和对照组患者术后并发症发生率及术后1、2年生存率比较差异无统计学意义(P>0.05)。对照组术后2年肿瘤复发率(44.44%)明显高于实验组(22.22%),差异有统计学意义(P<0.05)。实验组患者术后3年生存率为80.00%,明显高于对照组的42.22%,两组比较差异有统计学意义(P<0.05)。结论术中区域性缓释化疗在中晚期食管癌综合治疗中能降低肿瘤的复发率,且不会引起术后并发症的发生。

Objective To evaluate the clinical effect of intraoperative regional extended release chemotherapy for advanced esophageal cancer,and provide an effective treatment for advanced esophageal cancer patients. Methods 90 patients with advanced esophageal cancer were selected from our hospital from January 2011 to 2016 and randomly divided into experimental and control groups,45 in each group;both groups were using esophageal cancer surgery treatment. The experimental group received mixing chemotherapy drugs locally implanted during surgery performed interstitial treatment,while the control group only performed simple surgery. Two groups of patients underwent conventional chemotherapy after surgery with the same chemotherapy regimen. The postoperative complications,chemotherapy side effects,recurrence and survival,etc. were compared between two groups. Results The incidence of postoperative complications,1 to 2-year survival rates and other aspects of experimental group and control group had significant differences（P〉0.05）. The 2-year recurrence rate of the control group（44.44%） was significantly higher than that of the experimental group（22.22%）（P〈0.05）.3-year survival rate of the experimental group（80.00%） was significantly higher than that of control group（42.22%）（P〈0.05）.Conclusion Intraoperative regional release chemotherapy in the comprehensive treatment of advanced esophageal cancer could reduce the recurrence rate of the tumor,and did not cause postoperative complications.