蠕虫感染对免疫相关性疾病的调控

Effect of helminth infections on the regulation of immune-related diseases

免疫相关性疾病包括过敏性疾病和自身免疫性疾病等。过敏性疾病以速发型过敏反应为主,而自身免疫性疾病是机体对自身抗原发生免疫反应而导致自身组织器官损害的疾病。研究认为蠕虫感染率的下降很可能与免疫相关性疾病的增加密切相关。本文综述了蠕虫感染对哮喘、多发性硬化、系统性红斑狼疮、类风湿关节炎、炎症肠病和I型糖尿病等的免疫保护机制,包括Th1转为Th2表型的改变及上调T型和B型调节性细胞表型的表达等,探讨其临床应用前景和存在的问题。

Immune-related diseases comprised mainly allergic diseases and autoimmune diseases. Allergic diseases are characterized by the immediate hypersensitivity,while autoimmune diseases arise from the abnormal immune responses of the body against autoantigen,causing diffused damage to tissues and organs. It is reckoned that the decreased rate of helminth infections is closely related to the increased incidence rates of immune-related diseases. In this review,we focused on the possible protective mechanisms of helminth infection to asthma,multiple sclerosis,systematic lupus erythematosus,type I diabetes,etc.,including Th1 to Th2 shift and the up regulation of regular T cells and regular B cells,with the perspective that this knowledge may provide innovative avenues for their clinical applications as well as the problems encountered.