气滞胃痛颗粒联合乳果糖治疗便秘型肠易激综合征临床研究

Qizhiweitong Granule Combined with Lactulose in Treatment of Constipation Predominant Irritable Bowel Syndrome

目的:观察气滞胃痛颗粒联合乳果糖治疗便秘型肠易激综合征(irritable bowel syndrome,IBS)临床疗效。方法:将便秘型IBS患者90例分为两组,A组45例口服气滞胃痛颗粒+乳果糖,B组45例口服乳果糖,治疗8周。对比两组临床疗效。结果:A组有效率为93.33%,B组有效率为84.44%,两组有效率比较差异具有统计学意义(P<0.05)。两组患者疗程结束3个月随访期间疗效比较,A组有效率为88.89%,B组有效率为64.44%,两组有效率比较差异具有统计学意义(P<0.05)。治疗2周后统计两组患者排便次数和正常粪便性状比较,A组优于B组,差异均有统计学意义(P<0.05)。结论:气滞胃痛颗粒联合乳果糖治疗便秘型肠易激综合征疗效确切。

Objective ：To observe the clinical curative effect of Qizhiweitong Granule combined with lactulose in the treatment of constipation predominant irritable bowel syndrome （IBS） effect. Methods：90 patients with constipation type IBS were divided into tw9 groups,each of 45 cases. A group was given Qizhiweitong granule and lactulose, B group was given lactulose, treatment for 8 weeks. And clinical curative effect and adverse reactions were compared between the two groups. Results：The effective rate of A group was 93.33% , and B group was 84.44%, and the difference was statistically significant （P 〈 0.05 ）. After the end of the treatment,3 months follow-up, the effective rate of A group was 88.89%, and B group was 64.44%, and the difference was statis- tically significant （ P 〈 0.05）. After two weeks of treatment, defecation frequency and normal fecal characteristics of the two groups showed that A group was better than the B group, the difference was statistically significant （P 〈 0.05 ）. Conclusion ： The clinical curative effect of Qizhiweitong Granule combined with lactulose in the treatment of constipation predominant irritable bowel syn- drome is exact,less adverse reaction.