血液透析与血液灌流疗法改善糖尿病肾病透析者微炎症状态的作用

A controlled study of hemodialysis combined with hemoperfusion for the treatment of microinflammation in diabetic nephropathy

目的探究血液透析(HD)和血液灌流(HP)联合疗法对糖尿病肾病(DN)患者微炎症状态的影响。方法选择长江大学附属第一医院2014年1月至2015年12月的DN患者共计125例,分为观察组和对照组,观察组患者接受HD和HP联合疗法,对照组只接受HD疗法。比较两组治疗效果及微炎症检测结果。结果与对照组比较,观察组经治疗后总有效率达60.6%,对照组总有效率为45.8%(P<0.05);观察组患者外周血中IL-17、IL-6、IL-1β、IL-22、TGF-β1、TNF-α、SAA水平均呈降低趋势,与对照组比较,差异有统计学意义(P<0.01)。结论 HD和HP联合疗法能够改善DN患者体内的微炎症状态。

Objective The aim of this study was to assess the effect of hemodialysis combined with hemoperfusion for the treatment of microinflammation in diabetic nephropathy patients.Methods One hundred and twenty-five cases of diabetic nephropathy experienced treatment from July 2014 to December 2015 in author′s hospital were analyzed retrospectively.They were divided into two groups randomly.The observation group received hemodialysis combined with hemoperfusion,and the control group received just hemodialysis therapy.The status of microinflammation and curative effect were compared.Results The effective rate of observation group was 60.6%,while was 45.8% in control group（P〈0.05）.Microinflammation level：compared with control group,SAA,IL-6,IL-17,IL-22,IL-1β,TNF-αand TGF-β1status of observation group showed decreased trend（P〈0.01）.Conclusion Hemodialysis combined with hemoperfusion can effectively decreased microinflammation status in diabetic nephropathy.