有机光电材料在光声成像领域的应用

Organic Optoelectronic Materials for Photoacoustic Imaging

光声成像技术是采用"光激发声探测图像重建"的方法进行成像的一种新型分子影像技术。作为一种非侵害性的成像技术,光声成像既具备了声学成像技术穿透深度高的特点,也具备了光学成像技术高分辨率和高对比度的特性,克服了传统光学成像技术在成像深度与分辨率上不可兼得的缺陷。然而目前光声成像技术仍缺乏合适造影剂,严重制约了其应用与拓展,因此设计开发高效的光声造影剂是光声成像技术发挥其巨大潜能的关键。本文综述了五类有机光声造影剂(苝酰亚胺类、花菁类、BODIPY类、卟啉类和聚合物类)的研究进展,着重分析其结构与光学性质相关的构效关系,为有机光声造影剂的设计和开发提供指导,最后对有机光声造影剂存在的主要问题以及未来的热点方向进行了分析和展望。

Newly emerging photoacoustic imaging（PAI） technology that couples the advantages of optical imaging and ultrasound imaging allows a fascinating non-invasive imaging paradigm with higher spatial resolution and deeper imaging deepness when compared with traditional optical imaging techniques（e.g.,fluorescence）.Typically,PA contrast agents,which convert the absorbed photon energy into ultrasonic emission,are essential for a successful PA imaging.Although naturally occurring absorbers such as melanin and hemoglobin can serve as endogenous PA contrast agent to monitor anatomical and physiological variations in diseases,only small fractions of such endogenous contrast agents have been reported.Therefore,in order to fully explore the potential of PAI,exogenous PA contrast agents based on near-infrared（NIR,650-900 nm） absorption materials are urgently demanded.This article reviews the recent advances of organic optoelectronic materials in PAI such as small organic dye-based nanoparticles,polymer-based nanoparticles in biological imaging field.Then,we systematically summarize the structure properties relationship between contrast agents and the application of PAI to guide the design of new PA contrast agents.Finally,the future opportunities and challenges of PA contrast agents are discussed.