血浆和肽素水平对ST段抬高型急性心肌梗死患者住院期间主要不良心脏事件的评估意义

Significance of plasma copeptin level in patients with STEAMI in the assessment of MACE at the time of hospitalization

目的:探讨ST段抬高型急性心肌梗死(ST-segment elevation acute myocardial infarction,STEAMI)患者血浆和肽素水平对住院期间主要不良心脏事件(major adverse cardiac event,MACE)评估的意义。方法:选取100例STEAMI患者为观察组,选取同期行常规检查的100例稳定性冠心病患者为对照组,测定并比较两组患者血浆和肽素的水平;比较STEAMI患者中住院期间发生MACE与未发生MACE患者的血浆和肽素、肌酸激酶MB同工酶及血心肌肌钙蛋白Ⅰ的水平差异,并分析其对STEAMI患者住院期间发生MACE的预测价值。结果:观察组STEAMI患者的血浆和肽素水平高于对照组(P<0.05);STEAMI患者住院期间发生MACE组患者血浆和肽素、肌酸激酶MB同工酶及血心肌肌钙蛋白Ⅰ水平均高于未发生MACE组患者(P<0.05);血浆和肽素对于STEAMI患者住院期间发生MACE的ROC曲线下面积、灵敏度和特异度均高于肌酸激酶MB同工酶、血心肌肌钙蛋白Ⅰ(P<0.05)。结论:血浆和肽素水平可以有效预测STEAMI患者住院期间MACE的发生,具有较高的临床应用价值。

Objective：To evaluate the significance of plasma copeptin level in patients with ST- segment elevation acute myocardial infarction（STEAMI） in the assessment of major adverse cardiac events（MACE） at the time of hospitalization. Methods：100 cases of patients with STEAMI were selected as observation group and 100 patients with stable coronary heart disease were selected as control group. The plasma copeptin level in the two groups were measured and compared. And the plasma copeptin,creatine kinase MB isoenzyme and cardiac troponin I level differences in STEAMI patients with MACE and non- MACE during hospitalization were compared and the predictive value of MACE were analyzed. Result：The plasma copeptin level in observation group was higher than that in control group（ P〈0. 05）; The plasma copeptin,creatine kinase MB isoenzyme,and cardiac troponin I levels in patients with MACE during hospitalization were significantly higher than those in patients without MACE（ P〈0. 05）,and the area under the ROC curve,sensitivity and specificity of plasma copeptin in patients with MACE during hospitalization were higher than those of creatine kinase MB isoenzyme and cardiac troponin I（ P〈0. 05）. Conclusion：The plasma copeptin level can effectively predict the occurrence of MACE in STEAMI patients during hospitalization,which has a high clinical value.