支气管结核应用抗结核药联合支气管镜介入的临床疗效及安全性

Clinical efficacy and safety of anti- TB drugs treatment combined with bronchoscope intervention in the treatment of bronchial tuberculosis

目的:探讨支气管结核应用抗结核药联合支气管镜介入的临床疗效及安全性。方法:选取216例支气管结核患者,随机分为观察组(抗结核治疗+支气管镜介入)和对照组(抗结核治疗)各108例,对比两组临床疗效及安全性。结果:观察组总有效率高于对照组(P<0.05),痰菌转阴率高于对照组(P<0.05),治疗次数、住院时间和复发率均低于对照组(P<0.05),不良反应发生率与对照组比较差异无统计学意义(P>0.05)。结论:支气管结核应用抗结核药联合支气管镜介入的临床疗效较好,可有效提高痰菌转阴率,减少治疗次数和住院时间,降低复发率,安全性好,值得临床推广。

Objective：To investigate the clinical efficacy and safety of anti- tuberculosis（ anti- TB） drugs treatment combined with bronchoscope intervention in the treatment of bronchial tuberculosis. Methods： A total of 216 cases of patients with bronchial tuberculosis were selected and randomly divided into observation group（ anti- TB drugs ＋ bronchoscope intervention） and control group（ anti- TB drugs treatment）,108 cases in each group. The clinical efficacy and safety were compared between the two groups. Results： The total effective rate and sputum negative conversion rate in observation group were significantly higher than those in control group（ P〈0. 05）. Treatment times,hospitalization time and recurrence rate were significantly lower than those in control group（ P〈0. 05）. There was no significant difference in the incidence of adverse reactions between the two groups（ P〈0. 05）. Conclusion： The clinical effect of anti- TB drugs treatment combined with bronchoscope intervention in the treatment of bronchial tuberculosis is remarkable. It can effectively improve the sputum negative conversion rate and reduce the treatment times,hospitalization time and recurrence rate,so it is worthy of clinical promotion.