新生儿化脓性脑膜炎治疗及转归中降钙素原动态变化

Dynamic changes of PCT in the treatment and prognosis of neonatal purulent meningitis

目的:探讨在新生儿化脓性脑膜炎治疗及转归中的降钙素原(procalcitonin,PCT)动态变化的临床意义。方法:收集65例新生儿化脓性脑膜炎患儿临床资料,根据患儿临床预后分为痊愈组与预后不良组,比较两组患儿PCT动态变化。结果:65例患儿中,痊愈44例、预后不良21例。两组患儿治疗前PCT比较差异无统计学意义(P>0.05);治疗后48 h,痊愈组PCT水平下降,预后不良组PCT水平升高,与治疗前相比差异均有统计学意义(P<0.05);治疗后72 h,痊愈组PCT水平继续下降,而预后不良组PCT水平与治疗后48 h相比差异无统计学意义(P>0.05)。结论:动态监测化脓性脑膜炎治疗前后PCT的血清浓度变化,对于临床上判定新生儿化脓性脑膜炎的疗效及预后有重要的参考价值。

Objective：To explore the clinical significance of the dynamic change of procalcitonin（ PCT） levels in the treatment and prognosis of neonatal purulent meningitis（ PM）. Methods： The data of 65 cases of neonates with PM were collected and divided into cure group and poor prognosis group according to clinical prognosis. The dynamic changes of PCT were compared between the two groups. Results：There were 44 cases cured and 21 cases with poor prognosis in the 65 cases of children treated. Before treatment,there was no statistical significance in PCT levels between the two groups（ P〈0. 05）. 48 h after treatment,PCT level decreased in cure group and increased in poor prognosis group; there was significant difference compared with those before treatment（ P〈0. 05）. 72 h after treatment,PCT level in cure group continued to decline while PCT level in poor prognosis group had no statistical significance compared with that 48 h after treatment（ P〈0. 05）. Conclusion：Dynamic change of serum PCT levels in neonates with PM before and after treatment has a certain clinical value in judging the therapeutic effect and prognosis of neonatal PM.