三角形四肽重复干扰素诱导蛋白2在胃癌组织中的表达及预后

The expression of interferon - induced protein with tetratricopeptide repeats 2 in gastric cancer tissue and prognostic significance

目的探讨三角形四肽重复干扰素诱导蛋白2（IFIT2）在胃癌组织中的表达，并分析IFIT2的表达水平与胃癌患者临床病理特征及预后的关系。 方法采用免疫组织化学染色法检测胃癌组织芯片中90例胃癌组织和对应癌旁组织中IFIT2的表达，采用秩和检验比较胃癌及癌旁组织中IFIT2表达水平的差异，χ2检验分析IFIT2表达水平与患者临床病理特征的关系，采用Kaplan-Meier生存分析法分析IFIT2表达水平与患者总生存期关系，拟合Cox模型评价不同指标与患者预后的关系。 结果胃癌组织中IFIT2高表达比例（77.4%）显著低于癌旁组织（95.20%），差异有统计学意义（χ2＝11.334，P＝0.001）。Ⅲ～Ⅳ期胃癌组织中IFIT2高表达比例（72.00%）显著低于Ⅰ～Ⅱ期胃癌组织（90.91%），差异有统计学意义（χ2＝4.364，P＝0.037）。IFIT2高表达较IFIT2低表达胃癌患者总生存期（OS）延长，差异有统计学意义（χ2＝10.990，P＝0.001）。Cox模型分析结果显示远处转移[风险比（HR）＝2.693，95%可信区间（CI）：1.164～6.232，P＝0.021]、IFIT2高表达（HR＝0.350，95%CI：0.169～0.727，P＝0.005）可作为胃癌患者的预后因素。 结论IFIT2在胃癌的发生及发展中具有重要作用，可作为胃癌患者预后评估的重要风险因素。

Objective To discuss the expression of interferon - induced protein with tetratricopep- tide repeats 2 （IFIT2） in gastric cancer tissue, and to analyze the correlation of expression level of IFIT2 and clinical features and prognosis of gastric cancer patients. Methods Immunohistochemieal staining method was used to detect the expression of IFIT2 in 90 cases of gastric cancer tissue and corresponding normal adjacent tissues in tissue chip. The rank sum test was used to compare the difference in the expres- sion level of IFIT2 in gastric cancer tissue and corresponding normal adjacent tissue, and chi - square test was used to analyze the correlation of expression level of IFIT2 and clinical features. Kaplan - Meier meth- od was used to analyze the correlation of expression level of IFIT2 and overall survival, and Cox model was fitted to estimate the correlation of different indexes and prognosis. Results The high expression rate of IFIT2 in gastric cancer tissue （77.4%） was significantly higher than that in normal adjacent tissue （95.20% ,χ2= 11. 334,P= 0. 001 ）. The high expression rate of IFIT2 in stage Ⅲ- Ⅵ （72. 00%, 36/50） was significantly lower than that in stage Ⅰ -Ⅱ（90. 91% , 30/33 ; χ2 =4. 364, P =0. 037）. Patients with higher expression level of IFIT2 had longer OS than that with lower expression level with the difference being statistically significant （χ2 = 10.990, P = 0.001 ）. The Cox regression model indicated that distant metastasis [ hazard ratio（HR） =- 2. 693, 95% confidence interval （CI） ： 1. 164 - 6. 232, P = 0. 021 , and IFIT2 high expression （HR = 0. 350, 95% CI：O. 169 - 0. 727, P = 0. 005 ） were independent prognostic factors of gastric cancer. Conclusion IFIT2 had important effect in initiation and development of gastric cancer, and could serve as an important risk factor to predcit gastric cancer prognosis.