慢病毒载体在肿瘤基因治疗中的研究进展

Progress of ientiviral vector in cancer gene therapy

肿瘤基因治疗依赖于高效、安全、稳定的基因转导方法，慢病毒以其转染率高、靶向性强、表达稳定等优点脱颖而出，为肿瘤治疗带来了新的曙光。近年来，慢病毒载体逐渐成熟的设计、逐步完善的生产工艺、不断提高的安全性使其拥有广阔的应用前景；慢病毒在肿瘤疫苗制备、嵌合抗原受体修饰T细胞、介导自杀基因、RNA干扰及抑制肿瘤血管生成等方面的研究进展，不仅促进了肿瘤基因治疗的发展，更助力于肿瘤治疗进入精准医学新时代。

Cancer gene therapy rephes on efficient, safe and stable gene transduction. Lentiviral vector （LVs） stands out due to its good performance, which brings new hope to cancer treatment. In recent years, exquisite design, improved production process and advanced safty endow LVs broad prospects for application. The progresses of LVs in cancer vaccine production, chimeric antigen receptor - engineered T cells, suicide gene therapy, RNA - mediated interference, inhibition of tumor angiogenesis, help not only the development of cancer gene therapy, but also the practice of precision medicine.