有机质谱应用于抗体类药物结构解析的研究进展

Research Progress on Application of Organic Mass Spectrometry in Structural Analysis of Antibody Drugs

抗体类药物因其靶向性,能够直接与目标特异结合,并且药物副作用小、毒性低,在临床上具有广阔的应用前景。质谱(MS)以其快速、高灵敏度和高分辨率成为抗体药物结构分析的重要手段,为药物的质量控制和安全性方面提供了强有力的技术支撑。该文针对快速发展的有机质谱技术在抗体类药物的氨基酸序列、高级结构以及修饰鉴定方面的应用进行了综述。

With their targeting abilities,small sid-effects and low toxicity,antibody drugs could be directly combined with target specific,and they have broad application prospects in clinical practice.With its rapidness,high sensitivity and resolution,mass spectrometry（MS） has become an important means to analyze the structure of antibody,which provides a strong technical support for quality control and safety of the drug. In this paper,the rapid application development of organic mass spectrometry in the consistency of the amino acid sequence of antibody class,advanced structure and post translational modification（PTMs） are reviewed.