竹叶石膏汤联合麦门冬汤治疗耐药社区获得性肺炎临床研究

Clinical Study of Using Zhuye Shigao Decoction Combined with Maimendong Decoction in the Treatment of Drugresistant Community-acquired Pneumonia

目的:观察竹叶石膏汤联合麦门冬汤治疗耐药社区获得性肺炎的临床效果;方法:将83例耐药社区获得性肺炎患者,根据中药使用与否分为两组,治疗组39例,对照组44例。两组均予以基础治疗及盐酸莫西沙星氯化钠注射液抗感染治疗,治疗组在此基础上加用竹叶石膏汤联合麦门冬汤治疗。对两组细菌耐药情况进行分析,比较治疗前及治疗后1周、2周中医证候积分情况,比较两组疾病疗效及细菌疗效,监测其安全性。结果:两组耐药菌均以G-为主,病原菌及耐药菌分布均无明显差异;中医证候积分在治疗前无明显差异,在治疗后均下降,在治疗后第1周、第2周,治疗组均低于对照组,差异明显(P<0.05);疾病疗效方面,治疗组总有效率(97.44%)优于对照组(88.64%),细菌学疗效方面,治疗组总有效率优于对照组(91.30%VS 85.48%),差异均有统计学意义(P<0.05);两组在治疗中,均未见不良反应发生。结论:联合竹叶石膏汤和麦门冬汤治疗耐药社区获得性肺炎,不仅可明显改善临床症状,还可显著提高疾病疗效及细菌疗效,安全性良好,值得进一步推广。

Objective： To observe the clinical effect of using Zhuye Shigao Decoction combined with Maimendong Decoction in the treatment of drug-resistant community-acquired pneumonia. Methods ： 83 cases of drug-resistant community-acquired pneu- monia patients, according to the use of traditional Chinese medicine and divided into two groups, 39 cases in the treatment group, 44 cases in the controlled group, the two groups were given basic treatment and Moxifloxacin Hydrochloride and Sodium Chloride Injection anti-infection treatment, the treatment group was given Zhuye Shigao Decoction combined with Maimendong Decoction on the basis of the treatment of bacterial resistance ; two groups were analyzed before and after treatment in 1 weeks and 2 weeks of treatment of TCM syndrome integral comparison, two groups of comparative efficacy of diseases and bacterial efficacy, safety mo- nitoring. Results： Two groups of drug resistant bacteria in G-, there were no significant difference between the distribution of pathogenic bacteria and drug resistance; no significant difference between the TCM syndromes before treatment, after treatment were decreased in first weeks after the treatment, the 2 weeks. The treatment group weas lower than those of the controlled group, and the difference was significant （ P 〈 0. 05 ） ; the curative effect of the disease, the total efficiency rate of the treatment group was 97. 44%, was better than the controlled group, the rate was 88. 64%, bacteriological efficacy, the total efficiency of the treatment group was better than that of the controlled group （91. 30% vs 85. 48% ）, the differences was statistically significant （P 〈 0. 05） ; two groups in treatment, showed no adverse reaction occurred. Conclusion ： Combining Zhuye Shigao Decoction and Maimendong Decoction for treating drug-resistant community obtained pneumonia, not only can significantly improve the clini- cal symptoms, but also significantly improve the curative effect of the disease and bacterial efficacy, security is good, worthy of further promotion.