滋阴清肺汤结合聚乙二醇滴眼液治疗肺阴不足型干眼症临床疗效观察

Clinical Curative Observation of Using Ziyin Qingfei Decoction Combined with Polyethylene Glycol Eye Drops in the Treatment of Lung-Yin Deficiency Type Dry Eye Syndrome

目的:观察滋阴清肺汤结合聚乙二醇滴眼液治疗肺阴不足型干眼症的临床疗效,并对对其作用机制进行探讨。方法:选取115例肺阴不足型干眼症患者,将所选患者随机分为2组,对照组57例,观察组58例。对照组给予聚乙二醇滴眼液滴眼,每次1~2滴,每日3~4次。观察组在对照组治疗的基础上采用滋阴清肺汤治疗,每日1剂,分早晚2次温服,治疗1个月后对2组患者均进行症状积分、泪液中炎性因子以及疗效进行比较。结果:2组患者症状积分治疗后较治疗前积分明显降低(P<0.05),且观察组显著优于对照组(P<0.05);2组治疗后炎性因子指标比较,观察组泪液中IL-1β、IL-6及TNF-α水平明显较对照组低(P<0.05);对照组总有效率75.4%,观察组总有效率为91.4%。结论:滋阴清肺汤结合聚乙二醇滴眼液治疗肺阴不足型干眼症的疗效显著,其作用机制可能与降低IL-1β、IL-6及TNF-α的表达相关,值得临床上广泛应用。

Objective： Observing the clinical research and to explore its mechanism of using Ziyin Qingfei Decoction com- bined with polyethylene glycol （PEG） eye drops in the treatment of lung-Yin deficiency syndrome. Methods： 115 patients with stagnation of liver-Qi stagnation type non alcoholic fatty liver patients were selected. The selected patients were randomly divided into two groups which were controlled group （57 cases） and observation group （58 cases）. The controlled group were treated with polyethylene glycol （PEG） drops of eye drops eye drops, every time 1-2 drops, 3 to 4 times a day. The observation group was given Ziyin Qingfei Decoction treatment, daily 1 agent, sooner or later 2 lukewarm take on the basis of the controlled group, 2 groups of patients were treated for 1 month after for efficacy evaluation. Results ： After treatment in the two groups were inflamma- tory factors compared the observation group in tears of the patients with IL-1, IL-6 and TNF-α level was significantly lower than that of the controlled group （ P 〈 0. 05 ） ; the treatment efficiency rate of the controlled group was 75. 4%, and the total effec-tire rate of the observation group was 91. 4%. Conclusion： The curative effect of using Ziyin Qingfei Decoction combined with polyethylene glycol （PEG） eye drops in the treatment of lung-Yin deficiency type dry eye syndrome is remarkable, its mechanism may be related to reduce IL-1, IL-6 and TNF-α expression, it is worthy of wide clinical application.