西替利嗪中间体1-[(4-氯苯基)苯甲基]哌嗪的合成

Synthesis of 1-(4-chlorobenzhydryl) Piperazine of the Cetivizine Intermediates

以4-氯二苯甲酮为起始物料通过还原、氯代、取代反应合成了左旋西替利嗪的关键中间体1-[(4-氯苯基)苯甲基]哌嗪,总收率达到67%。

Using 4 - chlorbenzophenone as starting material 1 - （4 - chlorobenzhydryl） piperazine, the key intermediates of levocetirizine is synthesized by reduction, chlorination, substitution reaction, the total yield is 67% .