环糊精准聚轮烷和聚轮烷基因递送载体系统的研究进展

Development of cyclodextrin-based pseudopolyrotaxane and polyrotaxane for gene delivery system

基于环糊精的准聚轮烷和聚轮烷作为一种新颖的基因递送载体材料,具有分子结构独特、生物相容性好、稀释稳定性高、易于功能化修饰等优点,在基因递送研究中得到了越来越多的关注,展现出极大的应用潜力。本文对环糊精准聚轮烷和聚轮烷基因递送载体的研究进展进行综述,为进一步构建高效低毒的基因递送载体提供理论指导。

Pseudopolyrotaxane and polyrotaxane based on cyclodextrin have many advantages,such as unique molecular structure,good biocompatibility,high dilution stability,easy to be functionally modified and so on,which attract more attention on great potentials for gene delivery vectors. In this paper,we summarized the development of cyclodextrin-based pseudopolyrotaxane and polyrotaxane reported in recent years in order to provide theoretical guidance for the further construction of gene delivery vectors with high efficiency and low toxicity.