子宫内膜复杂性增生中错配修复基因蛋白的表达

A Study on Protein Expressions of Mismatch Repair Genes in Complex Endometrial Hyperplasia

目的观察子宫内膜复杂性增生中错配修复基因蛋白的表达情况。方法收集50例子宫内膜复杂性增生患者的病理肿块标本,并对病理组织进行免疫组化检测。通过病历记录获取临床信息进行分析。结果在50例子宫内膜复杂性增生患者中,27例(54%)至少有一种错配修复基因表达缺失,18例(36%)有两种及以上的错配修复基因表达缺失,3例(6%)所有的4种错配修复基因表达均为阴性。结论针对子宫内膜复杂性增生患者应进行更全面的遗传基因检测,为子宫内膜癌的预防提供有效手段。

Objective To observe expressions of mismatch repair genes in complex endometrial hyperplasia.Methods A total of 50 samples of complex endometrial hyperplasia were collected,and immunohistochemical method was used to detect protein expressions of mismatch repair genes. Clinical information from case history was obtained and analyzed. Results Among the 50 patients with complex endometrial hyperplasia,27 patients（ 54%） had loss of expression of at least one of mismatch repair genes. 18 patients（ 36%） had loss of expression of two or more mismatch repair genes,and 3 patients（ 6%） had negative expressions of all the four mismatch repair genes. Conclusion Patients with complex endometrial hyperplasia should be given genetic gene detection more comprehensively,and effective ways should be provided for preventing cancer of endometrium.