血清维生素D水平与老年急性脑梗死患者预后的相关性研究

Crrelation research between serum Vitamin D levels and prognosis in elderly patients with acute cerebra linfarction

目的探讨血清25-羟维生素D[25(OH)D]水平与老年急性缺血性脑梗死患者预后的关系。方法检测218例老年急性脑梗死患者的血清25(OH)D水平。采用改良mRS评估患者1年后功能恢复情况。结果根据25(OH)D水平将患者分为极低水平组54例、低水平组54例、中水平组55例和高水平组55例。极低水平组、低水平组、中水平组和高水平组间血红蛋白、糖化血红蛋白、三酰甘油、高密度脂蛋白水平及1年mRS评分、预后良好率差异有统计学意义(均P<0.01)。调整干扰因素后,高水平组患者1年后功能恢复情况良好(OR=1.95,95%CI:1.13~3.26)。结论血清25(OH)D水平可以独立预测急性脑梗死患者功能恢复情况。

Objective To explore the relationship between serum 25-hydroxyvitamin D [ 25 （OH）D ] level and prognosis in elderly patients with acute ischemic cerebral infarction. Methods Serum 25 （OH） D level was measured of 218 patients with acute cerebral infarction. The prognosis at 1 year was assessed by modified Rankin scale （mRS）. Results According to 25 （OH） D level, patients were divide into lowest quartile group （ n = 54 ）, low quartile group （ n = 54）, middle quartile group （ n = 55 ）, high quartile group （ n = 55 ）. The levels of hemoglobin, glycosylated hemoglobin, triglyeerides, high density lipoprotein and mRS score after 1 year between the 4 groups had statistical differences （ all P 〈 0. 01 ）. After adjustment for confounders, the high quartile group had higher tendency for good functional outcome after 1 year （ OR = 1.95, 95 % CI： 1.13 - 3.26 ）. Conclusion Serum 25 （OH） D level is an independent predictor of functional outcome in patients with acute cerebral infarction.