贝伐单抗治疗湿性年龄相关黄斑变性患者SD-OCT形态学变化(英文)

SD-OCT morphological changes in wet age-related macular degeneration patients after bevacizumab treatment

目的:研究频域光学相干断层成像(spectral domain optical coherence tomography,SD-OCT)定量和定性检测指标在接受玻璃体腔内注射贝伐单抗的年龄相关性黄斑变性(agerelated macular degeneration,AMD)患者人群中的变化,以评估这些指标是否可以用于预测治疗后视力情况。方法:回顾性分析66眼61例未进行过AMD相关治疗的患者接受至少3mo玻璃体腔内注射贝伐单抗治疗的情况。治疗前后SD-OCT定量检测指标[中央视网膜厚度(central foveal thickness,CFT),外界膜(external limiting membrane,ELM)和椭圆区(ellipsoid zone,EZ)长度]和定性检测指标进行分析和比较。同时,分析这些指标和治疗前后的视力的相关性。结果:平均视力(Log MAR)、CFT、ELM和EZ长度治疗前为0.62±0.41、419.3±110.0μm、378.2±377.2μm和156.4±253.7μm,治疗后为0.53±0.44、325.8±117.9μm、547.1±421.5μm和173.1±207.1μm。治疗前视力和CFT(rs=0.27)、ELM长度(rs=-0.30)及ELM断裂(rs=0.43)有相关性。治疗后视力同样和治疗后ELM长度相关(rs=-0.40)。治疗后视力和治疗前视力(rs=0.66)、ELM长度(rs=-0.35)和ELM断裂(rs=0.46)相关。结论:研究显示:治疗前视力、ELM长度和ELM断裂可以用于预测治疗后视力。

AIM：To investigate the changes in spectral domain optical coherence tomography（SD-OCT） quantitative and qualitative parameters in a group of patients with age-related macular degeneration（AMD） that underwent bevacizumab intravitreal injections（IV）.We assessed if one or more of these parameters can be used as prognostic factors of the post treatment visual acuity（VA）.METHODS：Totally 66 eyes of 61 patients,with treatment naive AMD,that were treated with at least 3 monthly bevacizumab IV,were retrospectively studied.SD-OCT quantitative[central foveal thickness（CFT）,external limiting membrane（ELM） and ellipsoid zone（EZ）lengths]and qualitative parameters were studied and compared before and after IV.We also tried to establish correlation between these parameters and before/after treatment VA.RESULTS：Mean VA（logMAR）,CFT（μm）,ELM length（μm） and EZ length（μm） changed from pre-Ⅳ values of0.62±0.41,419.3±110.0,378.2±377.2 and 156.4±253.7 to post-Ⅳ values of 0.53±0.44,325.8±117.9,547.1±421.5and 173.1 ±207.1.There was correlation between pre-ⅣVA and pre-Ⅳ CFT（rs=0.27）,ELM length（rs=-0.30）and ELM disruption（rs = 0.43）.There was also correlation between post-Ⅳ VA and post-Ⅳ ELM length（rs=-0.40）.Post-Ⅳ VA showed correlation with pre-ⅣVA（rs = 0.66）,ELM length（rs =-0.35） and ELM disruption（rs=0.46）.CONCLUSION：In our study group pre-Ⅳ VA,ELM length and ELM disruption can be used as post-Ⅳ VA prognostic factors.