正常人黄斑中央凹无血管区域面积分析

Foveal avascular zone area in normal subjects

目的:运用光学相干断层扫描技术(optical coherence tomography,OCT)血流成像技术测量正常人黄斑中央凹无血管区域(foveal avascular zone,FAZ)面积并分析FAZ面积相关临床特征。方法:采用横断面研究。用RTVue-100光学相干断层扫描血流成像技术测量健康研究对象的138眼FAZ面积。FAZ面积与相关因素的相关性用单因素和多因素线性回归分析。采用配对t检验比较右眼与左眼FAZ面积的差异。Pearson相关性分析双眼FAZ面积的相关性。结果:所有研究对象的平均FAZ面积为0.30±0.11mm^2。男性研究对象平均FAZ面积为0.29±0.13mm^2,而女性为0.31±0.09mm^2,男性FAZ面积小于女性FAZ面积,但差异无统计学意义(t=-1.346,P=0.180)。FAZ面积与年龄、性别等临床基本资料无相关性。右眼平均FAZ面积为0.30±0.11mm^2,左眼平均FAZ面积为0.30±0.10mm^2,双眼差异无统计学意义(P=0.943)。双眼FAZ面积存在很强的相关性。结论:OCT血流成像技术可清晰观察并定量测量FAZ面积。FAZ面积与老龄、性别等因素无关,双眼FAZ面积呈对称性特征。

AIM：To measure the foveal avascular zone（FAZ） area and to investigate the characteristics of the FAZ area in normal eyes,using optical coherence tomography（OCT）angiography.METHODS：This was a cross-sectional study.The FAZ area was measured in 69 participants,for a total of 138 eyes,using RTVue-100 OCT.The relations between the FAZ area and the potential factors were evaluated by univariate and multivariate linear regression analysis.Differences between the right and left eyes were calculated,and values were compared by means of a paired t test.Pearson correlation analysis was performed to assess the relationships of the FAZ area between the right and left eyes.RESULTS：The mean FAZ area was 0.30±0.11mm^2 in all subjects.For the male subjects,the mean FAZ area was0.29±0.13mm^2,and for the female subjects 0.31±0.09mm^2,with no significant difference（t=-1.346,P=0.180）.The FAZ area did not correlate with all the potential factors.The mean FAZ area in the right eye was 0.30±0.11mm^2,and in the left eye was 0.30±0.10mm^2,with no significant difference（P = 0.943）.There was a strong correlation between the right and left eyes for the FAZ area.CONCLUSION：OCT angiography is a noninvasive method of visualizing and measuring the FAZ area in normal subjects.The FAZ area does not correlate with old age,sex and other factors.It shows significant interocular symmetry in normal subjects.