兰尼碱受体磷酸化在脓毒性心肌病中的作用

Ryanodine receptor phosphorylation in sepsis-induced cardiomyopathy

脓毒症是指是感染引起的全身性炎症反应，是感染、烧伤、严重创伤、大手术、病理产科、中毒及心肺复苏术后常见的并发症，也是诱发脓毒症性休克、多器官功能障碍综合征的重要原因。心脏作为脓毒症所致的多器官功能障碍的主要靶器官之一，脓毒症时常诱发不同程度功能障碍，而心功能障碍可导致脓毒症进一步恶化。兰尼碱受体是一种大分子复杂蛋白组成的受体，是Ca^2＋通道的成分之一，对于肌肉收缩和心脏节律的调节是必不可少的，参与调节肌浆网释放Ca^2＋。该文对脓毒症心功能衰竭时，钙离子通道中兰尼碱受体作一综述。

Sepsis is a systemic inflammatory reaction caused by infection, which is a common complication after bum, serious trauma, major surgery, pathological obstetrics, toxication and cardiopulmonary resuscita- tion. Simultaneously ,it＇s also an important cause which can lead to septic shock and multiple organ dysfunction syndrome. Heart is the target of multiple organ dysfunction caused by sepsis, leading to different degrees of cardiac dysfunction by sepsis and vice verse. Ryanodine receptor is macromolecule composed by complex protein structure, which is the major component of Ca^2＋ channels. It＇s the necessary factor to adjust muscle, cardiac rhythm and contraction. It is also involved in regulating sarcoplasmic reticulum to release Ca^2＋ . This article is to give a review of rvanodine receptors in cardiac dysfunction caused by sepsis.