Humanin与人类寿命的关系

Humanin and human longevity

生长激素／胰岛素样生长因子-1（growth hormone／insulin-like growth factor-1，GH／IGF-1）轴参与人类生长发育的全过程。研究显示，GH／IGF-1活性随着年龄的变化可能会影响人类的寿命。Humanin是一种新型的具有广谱神经及细胞保护作用的线粒体相关肽，Hormone及其衍生物在多种年龄相关性疾病中起重要的保护作用，如脑卒中、心肌缺血再灌注、动脉粥样硬化、2型糖尿病等。近年有报道，Hormone、GH／IGF-1轴和寿命三者之间存在一定的关系，血浆Hormone水平与GH／IGF-1轴的活性呈负相关，而与人类寿命呈正相关。另外，Hormone及其衍生物具有保护胰岛B细胞和提高胰岛素敏感性的作用，在未来有望成为新的防治糖尿病的有效手段。

GH/IGF-1 axis is involved in the whole process of human＇s growth, and its trait of activity would change in varied ages that might affect human longevity. Humanin is a novel mitochondrial-associated polypeptide which has wide-spectrum neural and cellular protection. Hormone and its derivatives play a positive role on a variety of age-related diseases, such as stroke, myocardial ischemia reperfusion, atherosclerosis, diabetes, etc. Recently,relevant studies show a negative correlation between the plasma level of Hormone and the activity of GH/IGF-1 axis, while a positive correlation between the plasma level of Hormone and human longevity. Additionally, evidences have demonstrated that Hormone and its derivatives can protect the beta cells as well as improve insulin sensitivity, which is greatly expected to become an effective means of prevention＇ and treatment to diabetes in the future.