紫癜(过敏性紫癜)古今文献诊治规律数据挖掘

Purpura(Allergic Purpura) Law of Diagnosis and Treatment of Ancient and Modern Literature Data Mining

目的:探讨中医药对紫癜(过敏性紫癜)的诊治规律,对紫癜(过敏性紫癜)古今文献进行数据挖掘,以便研究者以及学习者更系统全面地了解紫癜(过敏性紫癜),为临床更好地诊断、治疗紫癜(过敏性紫癜)提供理论依据,并从古今中医文献中总结出有效治疗的措施指导临床实践。方法:检索相关古代中医文献及国内发表的使用中医药治疗本病的临床文献,对过敏性紫癜的主要证型及用药规律及随证加减规律进行分析,并在数据整理的基础上采用Clementine 12.0、SPSS 19.0等统计学软件进行辨证用药关联规则分析、频次频数及聚类分析,以得到古今中医文献中关于紫癜(过敏性紫癜)的诊疗经验(规则)。结果:符合标准的古代中医文献34篇、现代临床文献共61篇,涉及中药分15大类,使用频次较高的中药类型依次是:居前5位的是清热药(33.7%)、止血药(21.0%)、补益药(12.4%)、利水渗湿药(7.0%)、活血化瘀药(5.5%),辨证分型主要有风热伤络证(31.4%)、血热伤络证(21.2%)、肝肾阴虚证(18.3%)、湿热伤络证(12.1%)、脾肾阳虚证(10.8%)、其他证型(6.2%)。结论:本研究验证了"风、湿、热、毒、瘀、虚"为过敏性紫癜的中医学病因,治疗上提倡早期清热解毒、凉血祛风,中期解毒化瘀、凉血止血,后期养阴活血、滋肾清利,用药过程中需根据阶段的不同而加用清热凉血药及补气血阴阳之品。

Objective ： To study the traditional Chinese medicine of diagnosis and treatment law of purpura, allergic purpura, purpura （ allergic purpura ）, ancient and modern literature for data mining, so that the researchers and learners system more comprehensive understanding of purpura （ allergic purpura ）, for clinical diagnosis, treatment, better purpura （ allergic purpura ） provides the theory basis, and from the ancient and modern literature s the measures of effective treatment of traditional Chinese medicine to guide clinical practice. Methods： To retrieve relevant ancient literature of traditional Chinese medicine and published in the domestic use of Chinese medicine in the treatment of the disease clinical literature, the main syndrome types of allergic purpura and medication rule and in the add and subtract rule is analyzed, and on the basis of the data collected using Clementine 12.0 dialectical medicine association rules analysis, in order to get in the ancient and modern literature of traditional Chinese medicine （ allergic purpura ） in the diagnosis and treatment experience of purpura （ rules ）. Results ： Conforming with 34 references in ancient Chinese medicine and modern clinical with 61 references, involved in traditional Chinese medicine （ TCM ）, divided into 15 categories Clementine 12.0 software association rules analysis results show that the application of correlation in formula is higher in the literature, in turn, is that the top five is heat medicine （ 28.8% ）, tonify deficiency （ 21.6% ）, hemostatic drugs （ 14.6% ）, promoting blood circulation to remove blood stasis drugs （ 10.2% ）, the water moisture penetration medicine （ 8.9% ）, syndrome differentiation type mainly has the wind heat injury syndrome （ 11.3% ）, toxic heat forced the fact （ 28.4% ）, hot and damp stasis syndrome （ 21.8% ）, Yin deficiency, the fire resistance （ 11.9% ）, spleen deficiency syndrome （ 8.4% ）, spleen and kidney deficiency syndrome （ 14.8% ）. Conclusions ： This study verifies the ＂wind, dampness, heat, toxin and blood stasis, deficiency＂ of allergic purpura in TCM etiology, it is advocated that clearing heat and detoxification, cooling blood and dispelling wind in early stage, clearing toxin and activating blood stasis, cooling blood and stopping bleeding in middle stage, tonifying Yin and activating blood, nourishing kidney and clearing stasis, according to different stags, clearing heat drugs and tonifying Qi, blood, Yin and yang drugs should be used in the process.