芪竭颗粒对盆腔炎性疾病后遗症患者血清SOD、MDA及血清炎症因子水平影响

Effects of Serum SOD,MDA and Inflammatory Factors by Qijie Granule in Patients with Pelvic Inflammatory Disease Sequelae

目的:探究芪竭颗粒对盆腔炎性疾病后遗症患者血清SOD、MDA及血清炎症因子水平的影响。方法:选择72例盆腔炎性疾病后遗症患者,随机分成2组,每组36例。对照组予头孢西丁静点以及口服强力霉素等抗生素治疗,治疗组给予芪竭颗粒治疗,连续服药2周,检测治疗前后血清SOD、MDA、炎症因子水平以及血液血流变,疗效以及安全性。结果:与治疗前比较,2组血清TNF-α、IL-1β、IL-8水平降低(P<0.05),MDA、症状积分降低(P<0.05),TGF-β1、SOD水平升高(P<0.05);与对照组比较,治疗组血清TNF-α、IL-1β、IL-8水平较低(P<0.05),MDA、症状积分较低(P<0.05),TGF-β1、SOD水平较高(P<0.05),全血黏度、血浆黏度、红细胞压积以及红细胞聚集指数指标较低(P<0.05),临床疗效较高(P<0.01),安全性较好。结论:芪竭颗粒对盆腔炎性疾病后遗症有较好临床疗效,明显改善症状以及炎性因子水平,促进盆腔血液循环,且能降低MDA水平,升高SOD水平,安全性较好。

Objective ： To investigate the effects of serum SOD, MDA and inflammatory factors by Qijie Granule in patients with pelvic inflammatory disease sequelae. Methods ： A total of 72 patients with pelvic inflammatory disease sequelae were collected and randomly divided into two groups with 36 cases in each group. Patients in the control group were treated by eefoxitin static point and oral doxyeycline antibiotie treatment, patients in the experiment group were treated by Qijie Granule, continuous medication 2 weeks, tested the serum SOD, MDA and inflammatory factors levels and blood hemorrheology, efficacy and safety before and after treatment. Results： Compared with before treatment,2 groups of serum TNF-α , IL-1 β and IL-8 levels decreased （ P〈0.05 ）, MDA and symptoms integral decreased （ P〈0.05 ）, TGF- β 1 and SOD levels increased （ P〈0.05 ）; compared with the control group, serum TNF- α , IL-1 β and IL-8 levels of the experiment group were lower （ P〈0.05 ）, MDA and symptoms integral were lower （ P〈0.05 ）, TGF- β 1 and SOD levels were higher （ P〈0.05 ）, whole blood viscosity, plasma viscosity, erythroeyte deposited and erythrocyte aggregation indexes were lower （ P〈0.05 ）, the clinical efficacy was higher （ P〈0.01 ）, better security. Conclusion： Qijie Granule in the treatment of patients with pelvic inflammatory disease sequelae has a better clinical efficacy, obviously improve symptoms and inflammatory factor levels, promote pelvic blood circulation, and can decrease the MDA level, increase SOD level has better security.