疏肝理脾汤治疗腹泻型肠易激综合征疗效观察

Clinical Observation of Shugan Lipi Decoction in the Treatment of Irritable Bowel Syndrome with Diarrhea

目的:观察疏肝理脾汤治疗肝郁脾虚型腹泻型肠易激综合征的临床疗效。方法:符合纳入标准的80例患者被随机分为治疗组和对照组各40例。治疗组给予自拟中药汤剂疏肝理脾汤口服;对照组给予复方谷氨酰胺肠溶胶囊(谷参肠安),每次3粒,每日3次,饭前口服;疗程4周。治疗结束后观察证候疗效,并通过肠易激综合征症状严重程度量表(IBS-SSS)及焦虑自评量表(SAS)、抑郁自评量表(SDS)观察主要症状和患者不良情绪的变化情况。结果:两组患者中医证候总有效率分别为87.50%和72.50%,治疗组优于对照组(P<0.05);通过对IBS-SSS及SAS、SDS量表进行分析,两组患者各主要症状和抑郁、焦虑状况均较治疗前有明显改善,但治疗组在改善腹痛程度、腹胀情况及生活干扰方面,以及在降低患者抑郁、焦虑程度上,疗效优于对照组(P<0.05)。结论:中药疏肝理脾汤治疗肝郁脾虚型腹泻型肠易激综合征疗效满意,并能明显改善患者抑郁和焦虑状况。

Objective ： To observe the therapeutic efficacy of oral Shugan Lipi Decoction on liver depression and spleen deficiency type irritable bowel syndrome with diarrhea （ IBS-D ）. Methods ： We selected 80 cases of liver depression and spleen deficiency type IBS-D, which were randomly divided into treatment group and control group, and each group contained 40 cases. The latter was given oral compound glutamine entersoluble capsules, 3 capsules a time, 3 times daily before meals, while the former was given Shugan Lipi Decoction. After 4 weeks of treatment, we observed the effect through irritable bowel syndrome symptom severity score （ IBS-SSS ）, self-rating anxiety scale （ SAS ） and self-rating depression scale （ SDS ）. Results ： The total effective rate of the traditional Chinese medicine syndromes in treatment group was 87.50%, which was better than 72.50% of the control group （ P〈0.05 ）. After the treatment, IBS-SSS, SAS, SDS in the treatment group and the control group were all significantly decreased. Compared with SAS and SDS in control group, the treatment group showed statistical difference （P〈0.05）. In improving abdominal pain, abdominal distention and life interference, it was better in the treatment group （ P〈0.05 ）. Conclusion：Shugan Lipi Decoction can improve the clinical symptoms and psychological symptoms and improve the quality of life of liver depression and spleen deficiency type IBS-D patients.