靶向给药系统研究进展

Advances of Targeted Drug Delivery System

靶向给药系统(TDDS)能选择性作用于病变部位,减少全身分布,减少用药剂量和给药次数,控制药物的释放,提高药效,降低毒副作用。目前多用来治疗癌症、肿瘤、炎症、寄生虫、结核病等病证。该文根据载体的不同进行分类,主要包括脂质体、微球、纳米粒、纳米囊、单克隆抗体偶联物等载体制剂类型,综述几种靶向药物载体的特点、制备方法及其研究成果。

Targeting drug delivery system （ TDDS ） can be selectively applied to the lesion, reduce systemic distribution, reduce the dosage and frequency of administration, controlled release of drugs, improve efficacy, reduced toxicity. Currently used for topical administration, used to treat cancer, tumors, inflammation, TB disease. According to the classification of different carrier matericals, sreveral targeted administration review, including liposomes, microspheres, nano etc.