阿司匹林与氯吡格雷联用对短暂性脑缺血发作患者的疗效观察

Effect of Aspirin Combined with Clopidogrel on Patients with Transient Ischemic Attack

目的探讨阿司匹林联合氯吡格雷治疗短暂性脑缺血发作的治疗效果。方法选取我院2014—2015年收治的100例短暂性脑缺血发作患者,按照随机数字表法分为观察组和对照组,各50例。两组中对合并高血压、2型糖尿病者采取常规对症治疗,对照组在常规对症治疗的基础上口服阿司匹林,观察组在对照组治疗基础上口服氯吡格雷,观察两组治疗效果。结果观察组总有效率88.0%,对照组总有效率60.0%,观察组总有效率明显高于对照组(P<0.05);治疗后观察组NIHSS评分明显低于对照组,差异有统计学意义(P<0.05);观察组复发率8.0%(4/50),脑梗死发生率2.0%(1/50),对照组复发率16.0%(8/50),脑梗死发生率10.0%(5/50),观察组均明显低于对照组(P<0.05)。结论阿司匹林联合氯吡格雷治疗短暂性脑缺血发作疗效显著,且可有效降低复发率。

Objective To investigate the effect of aspirin combined with clopidogrel on patients with transient ischemic attack （TIA）. Methods 100 TIA patients, from January 2014 to December 2015, were selected and divided into control group and experiment group randomly. The conventional treatment was applied to the patients with hypertension or type 2 diabetes in the two groups. Based on this, the control group was given aspirin while the experimental group was given clopidogrel combined with aspirin. The curative effect and incidence of adverse reactions during treatment were observed. Results The total effective rate of the experimental group was 88% while the control group was 60%. The difference between the two groups was significant （P〈0. 05 ）. After the treatment, the experimental group＇s NIHSS score was significantly lower than that in the control group （P〈0. 05 ）. The recurrence rate and cerebral infarction incidence rate in the experimental group were significantly lower than that in the control group with the experimental group 8%, 2% and the control group 16%, 10%. （P 〈 0. 05）. Conclusion Aspirin combined with clopidogrel has certain curative effect on the patients with transient ischemic attack and can effectively reduce the recurrence rate.