甲状腺全切术治疗原发性甲状腺功能亢进疗效及对患者心脏功能和肝功能的影响

The Effect of Total Thyroidectomy for Primary Hyperthyroidism and its Influence on Patients with Cardiac Function and Liver Function

目的:观察临床应用甲状腺全切术治疗原发性甲状腺功能亢进的效果及对患者心脏及肝功能的影响。方法:选取2014年7月至2015年8月在我院进行诊治的98例原发性甲状腺功能亢进患者,按随机平行分组法随机分为对照组和观察组各49例,对照组患者给予甲状腺次全切术治疗,观察组患者则应用甲状腺全切术治疗,对比分析两组患者治疗后的临床疗效及对患者心脏及肝功能影响。结果:治疗后观察组短暂性甲减发生率高于对照组,差异具有统计学意义(P<0.05),术后复发率及术中出血量、手术时间均低于对照组,差异具有统计学意义(P<0.05);治疗前两组患者各项心脏功能及肝功能指标比较均无差异,差异具有统计学意义(P>0.05),治疗后均较治疗前下降,差异具有统计学意义(P<0.05);组间比较,观察组患者下降程度高于对照组,差异具有统计学意义(P<0.05)。结论:临床应用甲状腺全切术治疗原发性甲状腺功能亢进效果显著,可明显改善心脏及肝功能,可在临床推广应用。

Objective： To observe the clinical application of thyroid full cut method for the treatment of primary thyroid function hyperfunction and its influence on patient＇s heart and liver function. Methods： 98 cases of primary hyperthyroidism in our hospital from July 2014 to August 2015 were randomly divided into control group and observation group （ n = 49 ）. Patients in the control group were treated with subtotal thyroidectomy, while the patients in the observation group were treated with total thyroidectomy. The clinical curative effect and impact on the patient＇s heart and liver function of patients in two groups were compared. Results： After treatment, the transient hypothyroidism incidence of patients in the observation group was significantly higher than the control group （ P〈0.05） , and the recurrence rate of postoperative bleeding and operation time were significantly lower than the control group （ P〈0.05 ）. Cardiac function and liver function indexes of patients in the two groups were no significant difference （P〉0.05 ）. Conclusion： Clinical application of total thyroidectomy in the treatment of primary hyperthyroidism has significant effect, can significantly improve the heart and liver function.