高同型半胱氨酸血症与急性脑梗死的相关性研究

Study on Correlations between Hyperhomocysteinemia as Well as Atherosclerosis and Acute Cerebral Infarction

目的:探讨血浆同型半胱氨酸水平是否可以作为诊断脑梗死急性期的早期生化检测指标,达到为临床早期诊断和治疗急性脑梗死提供相关的实验依据的目的。方法:选择96例急性脑梗死患者和90例体检健康者为研究对象,检测血浆hcy水平,并进行对比分析。结果:试验组(急性脑梗死组)的血浆hcy平均水平为(23.56±4.65)μmo L/L,显著高于对照组的hcy平均水平(11.28±2.19)μmo L/L,具有统计学显著性差异(P<0.05);试验组高同型半胱氨酸血症(Hhcy)患者46例,所占比例为47.9%,对照组Hhcy患者为10例,所占比例为11.1%,具有显著性差异(P<0.05)。结论:急性脑梗死患者的血浆hcy水平及Hhcy患病率明显高于正常人,Hhcy可能是脑梗死的危险因素之一。

Objective ： To study the correlation between hyperhomocysteinemia （Hhcy） and acute cerebral infarction and to explore the relationship between hcy level and acute cerebral infarction. Methods： 96 patients with acute cerebral infarction and 90 normal healthy subjects were selected as objects. The levels of hcy were comparatively analyzed. Results： The serum hcy level of patients with acute cerebral infarction（23. 56±4.651μmoL/L was significantly higher than that of the healthy group（11.28±2.19） μmoL/L; The Hhcy patient number of the acute cerebral infarction group was 46, and its proportion was 47.9%, while the Hhcy patient number was 10 of the healthy group and its proportion was 11.1%, that has a significant difference （P 〈0.05 ）. Conclusions： The Hhcy may be one of independent risk factor in acute cerebral infarction; the hcy level and the incidence of Hhcy of patients with acute cerebral infarction are significantly higher than normal people.