东菱迪芙联合依达拉奉对老年脑梗死患者血清血管内皮生长因子、同型半胱氨酸和肿瘤坏死因子α的影响

Effects of batroxobin combined with edaravone on levels of vascular endothelial growth factor,homocysteine and tumor necrosis factor-α in elderly patients with cerebral infarction

目的探讨东菱迪芙联合依达拉奉对老年脑梗死患者血清血管内皮生长因子(VEGF)、同型半胱氨酸(Hcy)和肿瘤坏死因子-α(TNF-α)的影响。方法选取140老年急性脑梗死患者,分为对照组和观察组各70例。对照组患者给予依达拉奉治疗,观察组在对照组基础上联合东菱迪芙治疗。比较2组临床疗效、NIHSS评分、血清VEGF、Hcy、TNF-α水平。结果观察组总有效率显著高于对照组(P<0.05)。治疗后,2组NIHSS评分、血清VEGF、Hcy、TNF-α水平比较,差异有统计学意义(P<0.05)。结论东菱迪芙联合依达拉奉治疗老年急性脑梗死患者效果良好。

Objective To explore the effects of batroxobin combined with edaravone on vascular endothelial growth factor（ VEGF）,homocysteine（ Hcy） and tumor necrosis factor-α（ TNF-α）in elderly patients with cerebral infarction. Methods A total of 140 elderly patients with acute cerebral infarction were divided into control group and observation group,70 cases in each group. The control group was given edaravone,while the observation group was given batroxobin and edaravone.The efficacy,NIHSS score,levels of serum VEGF,Hcy and TNF-α were compared. Results The total effective rate in the observation group was significantly higher than that in the control group（ P〈0. 05）. There were significant differences in NIHSS score and serum levels of VEGF,Hcy,TNF-αbetween two groups（ P〈0. 05）. Conclusion Batroxobin combined with edaravone is effective in the treatment of elderly patients with acute cerebral infarction.