防己黄芪汤对原发性肾病综合征水肿期患者的疗效及对24h尿蛋白、血清白蛋白、血脂的影响

Efficacy of fangji huangqi decoction in treatment of patients with primary nephrotic syndrome in edema period and its influence on 24h urinary protein,serum albumin and blood lipid

目的探讨防己黄芪汤对原发性肾病综合征(PNS)水肿期的疗效及对24 h尿蛋白、血清白蛋白、血脂的影响。方法选取80例原发性肾病综合征水肿期患者,随机分为观察组和对照组。对照组患者给予常规西医治疗,在此基础上观察组患者给予防己黄芪汤治疗。观察2组患者治疗效果,分析两种治疗方法对患者24 h尿蛋白、血清白蛋白、血脂的影响。结果观察组患者治疗有效率为90.00%,显著高于对照组的80.00%(P<0.05);治疗后,观察组患者PT、Alb显著高于对照组,24 h尿蛋白定量、TG、Chol水平显著降低(P<0.05)。结论在原发性肾病综合征水肿期患者治疗过程中,防己黄芪汤有利于缓解临床症状,提高血浆白蛋白水平,降低尿蛋白。

Objective To explore the efficacy of fangji huangqi decoction in treatment of patients with primary nephrotic syndrome in edema period and its influence on 24 h urinary protein,serum albumin and blood lipids. Methods A total of 80 patients with primary nephrotic syndrome in edema period were randomly divided into observation group and control group. The control group was treated with conventional western medicine,while the observation group was given fangji huangqi decoction on the basis of control group. Efficacy,changes of 24 h urinary protein,serum albumin and blood lipids were compared between two groups. Results The total effective rate of the observation group was 90. 00%,which was significantly higher than 80. 00% of the control group（ P〈0. 05）.After treatment,the Pt and ALB in the observation group were significantly higher than those in the control group,and 24 h urine protein quantitation,TG and Chol levels decreased significantly（ P〈0. 05）. Conclusion In the treatment of patients with primary nephrotic syndrome in edema period,fangji huangqi decoction can alleviate clinical symptoms,increase the level of plasma albumin and reduce urinary protein.