胰腺腺泡细胞和胰岛β细胞损伤修复及再生的研究进展

Research Progress of the Repairing and Regeneration of the Injured Pancreatic Acinar and β Cells

胰腺炎可引起胰腺腺泡及胰岛β细胞损伤,修复胰腺内、外分泌功能是胰腺炎治疗研究亟待解决的问题;胰腺损伤修复、胰腺干细胞及内、外分泌细胞的再生和调控再生信号通路(Notch、Hedgehog及Wnt信号)对其意义重大。而胰腺腺泡及胰岛β细胞的损伤修复、再生及调控胰腺内外分泌细胞的去分化、转化和再分化过程是目前研究的热点。

Pancreatitis can cause the injuries of acinar andβcells.After pancreatitis,the repairing of the function of exocrine and endocrine is a problem that should be solved urgently.It’s important to understand the repairing of pancreatic injury,pancreatic stem cells,regeneration,and the signal pathways（Notch,Hedgehog,Wnt）that regulate them for pancreatic diseases.This review aimed to summarize the new progress of the injuries of acinar andβcells,regeneration,and regulating the dedifferentiation,redifferentiation and transformation of exocrine and endocrine cells.