儿童侵袭性肺炎链球菌感染的临床特征与药敏分析

Analysis of clinical characteristics and drug sensitivity of invasive pneumococcal infections in children

目的探讨儿童侵袭性肺炎链球菌感染的临床特征与药敏,以指导临床合理用药。方法选择2015年1月至2015年12月在我院诊治的呼吸道感染患儿316例,收集患儿的痰液标本,进行肺炎链球菌的分离,同时选择红霉素、青霉素、万古霉素、克林霉素、复方新诺明等抗生素进行药敏分析。结果在316例患儿中,检出肺炎链球菌感染患儿72例,检出率为22.8%。72株肺炎链球菌都对红霉素耐药,对克林霉素与复方新诺明的耐药数为69株与48株,对青霉素耐药数为3株,对万古霉素都敏感。结论儿童侵袭性肺炎链球菌感染在临床上比较常见,对于红霉素、克林霉素、复方新诺明的耐药率高,青霉素万古霉素的耐药性比较低,需要积极加强控制管理。

Objective To investigate the clinical characteristics and drug sensitivity of invasive pneumococcal infections in children, and to guide the clinical rational use of drugs. Methods Three hundred and sixteen cases of children with invasive pneumonia infection in our hospital from January 2015 to December 2015 were selected. The sputum samples of all children were collected and streptococcus pneumonia was separated. The drug sensitivity of erythromycin, penicillin, ancomycin,clindamycin and cotrimoxazole were analyzed. Results In 316 cases, 72 cases of children with streptococcus pneumoniae were detected, the detection rate was 22.8%. Seventy-two strains of streptococcus pneumoniae were resistant to erythromycin, the number of drug resistance to clindamycin and cotrimoxazole for 69 strains and 48 strains, the number of resistant to penicillin was 3 strains, all streptococcus pneumoniae were sensitive to vancomycin. Conclusion Children with invasive pneumococcal infection is common in clinic, drug resistances to erythromycin, clindamycin and cotrimoxazole are high, while drug resistance to penicillin vancomycin is relatively low, it is needed to strengthen the control management actively.