针灸治疗对氯苯丙氨酸(PCPA)失眠模型大鼠基础研究进展

Research Progress of Acupuncture and Moxibustion Treatment for Insomnia Induced by PCPA

针灸干预治疗对氯苯丙氨酸(PCPA)诱导失眠模型大鼠的实验文献进行搜集、整理,发现与针灸改善失眠作用相关的基础研究主要集中在动物行为学、免疫功能、神经递质系统、氧化应激反应等方面,研究表明针灸是通过对这些异常的生物学行为或微观分子产生良性调节作用,以神经-体液调节为基础的多靶点、多途径发挥改善睡眠作用。本研究对这些研究文献进行综述,一方面表明了针灸促眠作用的有效性,为临床治疗提供依据,另一方面分析了当前探索针灸改善睡眠机制研究中存在的问题和不足,并对今后的研究提出了建议和期望。

This article collects and arranges the experimental literature documents about acupuncture treatment for insomnia rats induced by PCPA. The results show that the fundamental research ol acupuncture Ior treating insomnia mainly focuses on the basis of animal behavior, immune function, neurotransmitter systems, oxidative stress, etc. These studies show that acupuncture has the effect on improving sleep based on nervous - humoral regulation of multiple targets and pathways by producing benign adjustment to abnormal biological behavior or microscopic molecular. This literature review not only shows the effect of acupuncture on promoting sleep and provides the basis for clinical treatment, but it also analyzes the currently existing problems and shortcomings in the research of the mechanism of acupuncture and puts forward some suggestions and expectations for the future research.