脂代谢紊乱患者牙种植体稳定性的评价

Evaluation of Dental Implants Stability in Patients with Lipid Metabolism Disorder

目的研究脂代谢紊乱的牙列缺损患者种植义齿修复后唾液中炎性细胞因子表达和种植体稳定性,分析脂代谢紊乱患者的种植预后状况。方法将脂代谢紊乱的牙列缺损患者设为实验组,血脂健康的牙列缺损患者设为对照组,在种植前,种植后1个月、3个月收集患者唾液,ELISA方法检测唾液中的白细胞介素6(IL-6)、白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)表达,Osstell ISQTM共振频率无线分析仪检测种植体的稳定性,并用Florida探针检测牙周状况。结果 2组种植后探诊深度(PD)、出血指数(BI)、共振频率无线分析仪检测种植体稳定系数(ISQ)无统计学差异(均P>0.05)。2组种植前,种植后1个月、3个月ISQ值,IL-6、IL-1β、TNF-α表达比较差异有统计学意义(均P<0.05)。种植前实验组IL-6、IL-1β、TNF-α的表达高于对照组(均P<0.05);而实验组种植后3个月与对照组种植前IL-6、IL-1β、TNF-α的表达均无统计学差异(均P>0.05)。结论种植术后脂代谢紊乱患者同血脂健康者一样具有良好的种植体稳定性,即脂代谢紊乱患者同样可以取得良好的种植预后。

Objective To study the expression of inflammatory factors in the saliva and the stability of implants after implant denture repair in patients with dysplasia of the dentition defect,and to analyze the prognosis of patients with lipid metabolic disorder. Methods The dentition defect patients with lipid metabolism disorder were selected as the experimental group. Patients with lipid defect were selected as the control group. Saliva was collected before implantation,1 month and 3 months after implantation. ELISA method was used to detect IL-6,IL-1β and TNF-α. Osstell ISQTMradio frequency analyzer was used to detect the stability of the implants and the periodontal status was detected by Florida probe. Results There were no significant differences in the depth of implant probing（PD）,bleeding index（BI）and ISQ between the two groups by radio frequency analyzer（all P 0.05）. The levels of IL-6,IL-1β and TNF-α in the pre-implantation,1 month and 3 months after implantation were significantly higher than those in the control group（all P 0.05）. The levels of IL-6,IL-1β and TNF-α in the experimental group were significantly higher than those in the control group before planting（all P 0.05）3 months after planting,there were no significant differences of IL-6,IL-1β,and TNF-α between the experimental group and control group（all P 0.05）. Conclusion The patients with dyslipidemia after implantation have good implant stability as those with normal blood lipid,and the patients with dyslipidemia can also obtain good prognosis.