抗焦虑抑郁药物改善伴焦虑抑郁的原发性面肌痉挛症状有效性的研究

Anxiolytics and Antidepressants Contribute to Symptomatic Improvement in Patients with Primary Hemifacial Spasm Coupled with Anxiety and Depression

目的探讨抗焦虑抑郁药物改善伴焦虑抑郁的原发性面肌痉挛(HFS)患者症状的有效性。方法将60例伴焦虑抑郁的HFS患者分为2组。实验组给予A型肉毒毒素(BTX-A)+艾司西酞普兰治疗,对照组给予BTX-A治疗,于治疗前、后行焦虑自评量表(SAS)及抑郁自评量表(SDS)测评。结果 2组经治疗后症状均改善,治疗1周、1个月时2组间治疗效果无统计学差异;2周、3个月时实验组改善更明显。治疗后实验组平均SAS、SDS标准分较对照组下降明显,对照组于治疗后1个月及3个月较治疗前有统计学差异(P<0.05),实验组2周后较治疗前差异有统计学意义(P<0.05),1个月后2组间存在统计学差异(P<0.05),且实验组BTX-A有效期更长。结论焦虑、抑郁与病情呈正相关,为HFS的并发症,加用抗焦虑药物可使HFS治疗效果更佳。

Objective To evaluate the symptom improvement of anxiolytics and antidepressant to hemifacial spasm（HFS）patients with anxiety and depression. Methods A total of 60 HFS patients with anxiety and depression were enrolled for the study and divided into experimental group and control group. Experimental group were treated with escitalopram and BTX-A,and control group only received BTX-A. SAS and SDS were used to test all the patients before and after treatment. Results Both experimental group and control group were significantly improved after BTX-A therapy. There was no different between two groups at 1 week and 1 month,respectively. At 2 weeks and 3 months,more obvious improvement was seen in experimental group. The SAS and the SDS standard average scores of experimental group were significantly decreased compared with the control group. There was statistical significance in control group after 1 month and 3 months treatmen（P〈0.05）,and in experimental group,the differences appeared after 2-week treatment（P〈0.05）. Additionally,after 1 month treatment,there were statistical differences between the two groups（P〈0.05）,and experimental group shown a longer effective period compared with control group. Conclusion Anxiety and depression state serves as a complication of HFS,which is positively correlated with HFS. HFS patients with anxiety and depression benefit better from escitalopram and BTX-A combination therapy than BTX-A alone.