力学刺激下BMP信号通路影响成骨分化的研究进展

Research progress of the effect of BMP signaling pathway on the process of mechanically induced osteogenic differentiation

骨组织的再生和重塑涉及复杂的力学刺激,而机械性诱导骨改建是牵张成骨、骨缺损修复、正畸牙移动生物学的重要理论基础。骨形态发生蛋白(bone morphogenetic proteins,BMPs)是调控骨骼发育的关键信号分子,在骨组织的发生及再生中起着重要作用。研究表明,激活BMP信号可增强成骨相关标志性基因的表达,促进骨形成。本文就力学刺激下参与骨向分化的BMP信号通路的相关研究进行综述。

Clinically,mechanical stimulation is an important factor in enhancing the bone regeneration and remodeling,and mechanically induced bone reconstruction is the critical biological basis of distraction osteogenesis,bone defect restoration and orthodontic tooth movement. BMPs,as the key signaling molecule in the regulation of bone development,play a significant role in the occurrence and regeneration of bone tissue. It has been shown that the activation of BMP signaling can promote the expression of osteogenic-related genes and induce bone formation. This paper will summary the research progress of BMP signaling pathway in mechanically induced osteogenic differentiation.